肺保护性通气策略在新生儿呼吸窘迫机械通气治疗中的临床应用研究  

A Research on the Clinical Application of Lung Protection Ventilation Strategies in the Treatment of Newborns with RDS through Mechanical Ventilation

作　　者：王冬妹[1] 刘晓燕[1] 冯奔红[1] 

机构地区：[1]汕头大学医学院附属粤北人民医院新生儿科,韶关512026

出　　处：《数理医药学杂志》2015年第9期1287-1288,共2页Journal of Mathematical Medicine

摘　　要：目的：探讨肺保护性通气策略在新生儿呼吸窘迫综合征（RDS）机械通气治疗的临床效果.方法：某院在2010年1月~2014年1月收治的78例新生儿RDS患者,随机均分为对照组和观察组,观察组采用肺保护通气策略进行通气对照组采用传统方法进行通气,对两组呼吸机设置、血气分析结果等资料进行比较.结果：观察组呼吸机参数吸气峰压（PIP）和平均气道压（MAP）低于对照组,差异具有统计学意义（P 〈0.05）;观察组呼吸机相关性肺损伤（VALI）发生率2.6%低于观察组20.5%且差异具有统计学意义（P 〈0.05）.观察组动脉血二氧化碳分压（PaCO2）为（51.7±3.7）mmHg,对照组PaCO2为（41.31±3.11）mmHg,两组差异具有统计学意义（P 〈0.05）.结论：肺保护性通气策略能够显著减低VALI发生率,并且不增加CLD、PDA、IVH 的发生率,值得在临床上广泛推广.Objective:To investigate the effect of ventilation strategy for protecting lung on newborns with RDS treated through mechanical ventilation.Methods:Select 78 newborn patients received in some hospi-tal during the period from January 2010 to January 2014 and randomly divide them into observation group and control group,ventilate the observation group according to lung protection strategy and ventilate the con-trol group in traditional way.Compare the settings of respirator,the result of blood gas analysis and other da-ta.Results:In observation group,the PIP and MAP of respirator were lower than than in control group,the difference was statistically significant (P<0.05);the occurrence rate of VALI was 2.6%,which was lower than that of the control group(20.5%),and the difference was statistically significant (P<0.05);the PaCO2 of arterial blood in observation group was (51.7±3.7)mmHg,and the figure was 41.31±3.11)mmHg in con-trol group,the difference between the 2 groups was statistically significant (P<0.05).Conclusion:Lung pro-tective ventilation strategy can effectively reduce the occurrence of VALI and would not increase the occur-rence of CLD,PDA and IVH,it is worthy of widely clinical promotion .

关 键 词：肺保护通气策略 呼吸窘迫综合征 机械通气治疗 

分 类 号：R722.12[医药卫生—儿科]