无溶剂微波法辅助氧化铝催化傅氏酰基化反应  

Solvent-free Microwave-Irradiated Friedel-Crafts Acylation Catalyzed by Al2O3

作　　者：段新红[1] 

机构地区：[1]北京林业大学理学院

出　　处：《化学教育》2015年第16期30-32,共3页Chinese Journal of Chemical Education

基　　金：北京林业大学教学改革研究项目(BJFU2011JG033);北京林业大学国家级大学生创新训练项目(201210022072)

摘　　要：利用简单安全、快速有效的吲哚C3傅氏酰基化反应，开展本科生绿色有机化学实验教学。这一绿色合成方法采用无溶剂微波法取代常规加热、有机溶剂法；柱色谱级Al2O3代替传统的AlCl3催化剂。Al2O3不仅环境友好、价格便宜和易再生，而且具有高效的催化活性。通过这一实验，学生能亲身实践绿色有机合成，同时进一步巩固了芳香亲电取代反应及杂环化学的理论知识。This article proposed a safe, simple and rapid organic chemistry experiment, Friedel-Crafts 3-acylation of indole, to carry out green organic chemistry experiment teaching for undergraduates. This synthesis employing chromatographic-grade Al2O3 as an environment- friendly, inexpensive, reusable and effective catalyst to replace the traditional AlCl3, was carried out under solvent-free condition in a commercial microwave oven rather than using conventional heating in a hazardous solvent. The product could be easily isolated from Al2O3 and purified by recrystallization in ethanol. This experiment could allow students to experience the green organic synthesis and also help them to reinforce their knowledge of electrophilic substitution and heterocycle chemistry.

关 键 词：傅氏酰基化反应 无溶剂微波法 氧化铝催化剂 绿色有机化学 实验改进 

分 类 号：O621.251-4[理学—有机化学] G642[理学—化学]