2型糖尿病患者血清胆红素、纤维蛋白原与糖尿病肾病的相关性研究  

Relationship between serum bilirubin, fibrinogen and diabetic nephropathy in patients with type 2 diabetes mellitus

作　　者：张玉海[1] 刘海蔚[1] 陈道雄[1] 高勇义[1] 

机构地区：[1]海南省人民医院内分泌科,海南海口570311

出　　处：《海南医学》2015年第15期2205-2208,共4页Hainan Medical Journal

摘　　要：目的探讨2型糖尿病(T2DM)患者血清胆红素及纤维蛋白原与糖尿病肾病(DN)发生的关系。方法 629例T2DM患者,按照24 h尿白蛋白定量分为正常尿白蛋白组(A组)474例,微量尿白蛋白组(B组)100例,临床尿白蛋白组(C组)55例。并以146例正常成人作为对照组,观察各组之间血清胆红素和纤维蛋白原的差异,探讨胆红素及纤维蛋白原与DN相关性。结果 T2DM患者血清总胆红素、直接胆红素和间接胆红素水平均低于正常对照组(P<0.05),纤维蛋白原高于对照组(P<0.05)。C组总胆红素、间接胆红素、直接胆红素均较A组及B组降低(P<0.05),C组纤维蛋白原较正常A组及B组升高(P<0.05),B组总胆红素、间接胆红素、直接胆红素均较A组下降(P<0.05),B组纤维蛋白原较A组升高(P<0.05),将尿白蛋白与血清胆红素水平及纤维蛋白原作相关性分析,结果显示尿白蛋白与总胆红素、直接胆红素、间接胆红素呈负相关,相关系数分别为r=-0.191,P<0.05;r=-0.299,P<0.05;r=-0.184,P<0.05。尿白蛋白与纤维蛋白原呈正相关,相关系数为r=0.33,P<0.05。总胆红素、直接胆红素、间接胆红素与纤维蛋白原呈负相关,相关系数分别为r=-0.128,r=-0.189,r=-0.207,P<0.05。结论胆红素和纤维蛋白原与糖尿病肾病的发生相关。Objective To explore the relationship between serum bilirubin, fibrinogen （Fib） and diabetic ne-phropathy （DN） in patients with type 2 diabetes mellitus （T2DM）. Methods A total of 629 T2DM patients （T2DM group） were classified into normoalbuminuria group （group A, n=474）, microalbuminuria group （group B, n=100） and macroalbuminuria group （group C, n=55） according to the degree of urinary albumin excretion. We randomly chose 146 healthy adults as the control group. The difference in serum bilirubin, Fib among groups and the correlation be-tween serum bilirubin, Fib and diabetic nephropathy were analyzed. Results T2DM group had significantly lower levels of serum total bilirubin, direct bilirubin and unconjugated bilirubin than the control group （P〈0.05）, and signifi-cantly higher FIB levels （P〈0.05）. Compared with the other two groups, group C had significantly lower serum total bil-irubin, direct bilirubin as well as unconjugated bilirubin （P〈0.01）, and significantly higher Fib levels （P〈0.01）. The total bilirubin, direct bilirubin and unconjugated bilirubin levels of group B were significantly lower compared with those of group A （P〈0.05）, while the Fib levels were significantly higher （P〈0.05）. The correlation analysis showed that the cor-relation coefficients of urinary albumin to serum total bilirubin, direct bilirubin, unconjugated bilirubin and Fib were r=-0.191, P〈0.05; r=-0.299, P〈0.05; r=-0. 184, P〈0.05; r=0.33, P〈0.05, respectively. The correlation analysis also showed that the correlation coefficients of Fib to serum total bilirubin, direct bilirubin and unconjugated bilirubin were r=-0.128, r=-0.189,r=-0.207, P〈0.05, respectively. Conclusion Serum bilirubin and Fib are correlated to DN.

关 键 词：2型糖尿病 糖尿病肾病 胆红素 纤维蛋白原 

分 类 号：R587.1[医药卫生—内分泌]