替罗非班在急性心肌梗死介入治疗中的疗效及安全性  

Efficacy and safety of the treatment of patients with acute myocardial infarction in patients with acute myocardial infarction

作　　者：昌思梦 衡明强 李志军[1] 李世春[1] 陈国梁[1] 臧滔[1] 王福江[1] 胡秀玲[1] 

机构地区：[1]新疆昌吉州人民医院心内科,新疆昌吉831100

出　　处：《中西医结合心血管病电子杂志》2015年第9期10-11,共2页Cardiovascular Disease Electronic Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察替罗非班在急性ST段抬高性心肌梗死（STEMI）经皮冠状动脉介入治疗（PCI）中的有效性及安全性。方法选择2011年5月~2014年5月我院接受急诊冠状动脉介入治疗的急性ST段抬高性心肌梗死患者180例作为研究对象,随机分为替罗非班组和对照组,各90例。比较两组患者术后7天心电图ST段回落情况、左室射血分数、术后梗死相关血管开通后血流TIMI分级、术后30天内出血并发症及主要不良心脏事件的发生情况。结果术后7天内心电图ST段回落情况,替罗非班组所占比例高于对照组、替罗非班组TIMI血流3级高于对照组、替罗非班组左室射血分数高于对照组、30天内主要不良心脏事件的发生率替罗非班组低于对照组,差异有统计学意义（P〈0.05）,而两组术后30天内出血并发症比较,差异无统计学意义（P〉0.05）。结论在急性STEMI介入治疗中,盐酸替罗非班的应用,能明显改善心肌再灌注、改善梗死相关血管的TIMI血流、提高心脏射血分数而改善心脏功能、减少心脏不良事件的发生,且不增加临床出血风险,临床应用价值高。Objective To observe the efficacy and safety of the percutaneous coronary intervention（PCI） in patients with acute ST segment elevation myocardial infarction（STEMI）. Methods From May 2011 to May 2014, 180 patients with acute ST segment elevation myocardial infarction treated by emergency percutaneous coronary intervention were randomly divided into the control group and the control group. The 7 groups were compared with two days after operation. The patients with ST segment of ECG, left ventricular ejection fraction, blood flow TIMI after operation and 30 days after operation. Results In 7 days after operation, the ST segment of ECG was lower than that of the control group, the left ventricular ejection fraction of the left ventricular ejection fraction was significantly higher than the control group（P〈0.05）, and the difference was statistically significant（P〉0.05） between 30 groups（TIMI）. Conclusion The application of TIMI in the treatment of patients with acute ST segment elevation myocardial infarction can significantly improve myocardial reperfusion, improve the blood flow of infarction related blood vessels, improve cardiac function and reduce the incidence of cardiac adverse events.

关 键 词：替罗非班 急性心肌梗死 经皮冠状动脉介入治疗 

分 类 号：R541[医药卫生—心血管疾病]