舒尼替尼相关性急性胆囊炎2例报告并文献复习  

Sunitinib-related acute cholecystitis(a report of 2 cases and literature review)

作　　者：宋彦平[1] 刘南[1] 戴君勇[1] 李元[1] 鲜鹏[1] 李俊[1] 唐显力[1] 周宏[1] 罗宏[1] 

机构地区：[1]重庆市肿瘤研究所泌尿外科,重庆400030

出　　处：《现代泌尿外科杂志》2015年第8期574-576,共3页Journal of Modern Urology

基　　金：重庆市卫生局医学科研计划项目(No.2012-2-495)

摘　　要：目的探讨舒尼替尼相关性急性胆囊炎的临床诊治。方法回顾性分析2例舒尼替尼相关性急性胆囊炎的临床资料,结合文献复习讨论。结果 2例患者为男性,年龄分别为58、50岁,均为转移性肾透明细胞癌患者,行口服舒尼替尼靶向治疗。发病时间为口服舒尼替尼1年半及第2周期,均表现为突发右上腹疼痛感。查体:墨菲氏征阳性。B超均提示胆囊增大,壁增厚。临床诊断:急性胆囊炎,应用国际通用的药品不良反应评价表评分提示2例病例与口服舒尼替尼相关性分别为很可能相关及可能相关。1例经停服舒尼替尼,禁食、广谱抗生素抗炎、支持治疗1周后治愈,另1例经保守治疗失败后行胆囊切除术。结论舒尼替尼相关性急性胆囊炎发病急,对患者危害大,应引起临床重视。Objective To explore the diagnosis and management of Sunitinib-related acute cholecystitis. Methods Clinical data of 2 cases of Sunitinib-related acute cholecystitis were retrospectively analyzed and relevant literature was reviewed. Results Both patients were male, aged 58 years and 50 years respectively. Both suffered metastatic clear cell renal cell carcinoma and were treated with oral Sunitinib. The onset time of acute cholecystitis was 1.5 years after and 2 cycles of treatment. Both cases were characterized with sudden right epigastric pain with positive murphy＇s. The cholecysts were bigger and the walls thickened as revealed by B ultrasound. Both cases were diagnosed as acute cholecystitis. One case was cured 1 week after Sunitinib was stopped, broad-spectrum antibiotics were used, and fasting. Another cases received cholecystectomy after failure of conservative treatment. Conclusions Attention must be paid to Sunitinib-related acute cholecystitis.

关 键 词：舒尼替尼 肾透明细胞癌 急性胆囊炎 诊断 治疗 

分 类 号：R657.4[医药卫生—外科学]