3种呼吸道疾病检测过敏原特异性IgE抗体的临床意义  

Clinical significance of three kinds of respiratory disease detection of allergen specific IgE antibody

作　　者：蒋丽佳[1] 董艳芬[1] 刘乾[1] 夏蕾[1] 范静[1] 

机构地区：[1]常州市第二人民医院,江苏常州213003

出　　处：《常州实用医学》2015年第4期237-240,共4页CHANGZHOU PRACTICAL MEDICINE

摘　　要：目的探讨慢性阻塞性肺气肿（COPD）、支气管哮喘以及支气管哮喘合并COPD患者检测过敏原特异性IgE抗体的临床意义。方法采用免疫印迹法对3种呼吸道疾病患者的血清进行定量检测特异性过敏原IgE及总IgE水平。结果COPD、哮喘及哮喘合并COPD患者总IgE阳性率分别为50．0％、61．6％和51．8％，3组患者间tlgE无显著差异；哮喘以及哮喘合并COPD患者吸入物过敏原IgE（sIgE）的阳性率明显高于食入性过敏原，这2组患者吸入物过敏原IgE的阳性率分别为96．7％和88．9％，主要以户尘螨、屋尘、猫狗的毛发皮屑、霉菌为主；食入性过敏原阳性率为37．3％和41．7％，主要以牛奶、羊肉、牛肉、鸡蛋白为主；吸入性过敏原及食入性过敏原阳性率在COPD与哮喘组间差异有统计学意义（P〈0．01）。结论吸入性过敏原与哮喘及COPD的发生均关系密切，血清过敏原特异性IgE的检测可为呼吸道疾病的鉴别及防治提供科学依据。Objective Chronic obstructive pulmonary disease（COPD）,bronehial asthma（asthma）and Asthma Combing with COPD allergens and clinical significance. Methods Asthma and asthma combing with COPD and allergen- specific IgE and total IgE levels were quantitatively detected and analyzed for common allergens and distribution of species. Results COPD pa- tients（tlgE） positive rate was 50.0% （17 cases）,61.6% （61 cases）and 51.8% （14 cases）,in the three groups of patients tlgE, there was no significant difference. Asthma and asthma combing with COPD inhalant allergens IgE（slgE）was significantly higher than the ingestion of allergens, these two groups of patients with inhalant allergens were positive rate of 96.7 % and 88.9 %, mainly in household dust mites, house dust, eats and dogs dander, mold- based; ingested allergens positive rate was 37.3 % and 41.7 %,mainly milk, mutton, beef, egg white- based, tIgE is no sigruficant differences among the three groups of patients, inhaled allergens and food allergens positive rate between COPD and asthma patients was statistieaUy significant（p 〈 0.01）differences. Conclusion Inhaled allergens associated with asttmaa and COPD are closely related to the occurrence of which serum allergen - specific IgE testing can provide a scientific basis for the identification and prevention of respiratory disease.

关 键 词：慢性阻塞性肺气肿 哮喘 过敏原 特异性IGE 检测 临床意义 

分 类 号：R446.6[医药卫生—诊断学]