阿托伐他汀钙联合硝苯地平缓释片治疗轻中度高血压合并心脏病的疗效与肝肾功能影响  

The effect of atorvastatin calcium combined with extended release nifedipine tablets in the treatmernt of tmild to moderate hypertension with heart disease and its effect on liver and kidney

作　　者：刘左玲 刘衍宇[1] 凌云[1] 陈晓[1] 许锦荣[1] 方凌燕[1] 

机构地区：[1]广东医学院第二附属医院心血管内科,广东湛江524003

出　　处：《中国医药科学》2015年第11期66-68,共3页China Medicine And Pharmacy

摘　　要：目的阿托伐他汀钙联合硝笨地平缓释片治疗轻中度高血压合并心脏病的临床疗效及其对肝肾功能的影响。方法随机将150例轻中度高血压合并左室肥厚患者分为两组,对照组给予硝苯地平缓释片治疗,治疗组在此基础上加用阿托伐他汀钙治疗。治疗18个月后,比较两组血压、左室后壁厚度(LVPW)和室间隔厚度(IVS)及肝肾功能。结果两组治疗后血压均达标,治疗组收缩压、舒张压下降较对照组明显。两组LVPW和IVS均有所改善,治疗组改善更加明显。治疗组有2例患者出现转氨酶升高而停用阿托伐他汀钙,对照组无1例发生肝肾功能损害。结论阿托伐他汀钙联合硝苯地平缓释片联合治疗轻中度高血压合并左室肥厚患者疗效更优,且无明显肝肾损害。Objective To ivvestigate the clinical effect of Atorvastatin calcium combined with Extended Release Nifedipine Tablets in the treatment of mild to moderate hypertension complicated with heart disease its effect on liver and renal function.Methods 150 patients with mild to moderate hypertension and left ventricular hypertrophy were divided into two groups,the control group was given Extended Release Nifedipine Tablets,the treatment was given atorvastatin calcium in addition to Extended Release Nifedipine Tablets.After 18 months of treatment,The blood pressure,left ventricular posterior wall thickness（LVPW）,ventricular septal thickness（IVS） and the function of liver and kidney were compared between the two groups. ResultsThe blood pressure of the 2 groups after treatment were standard.The systolic pressure,diastolic pressure decreased more significantly in the observation group than the control group.The LVPW and IVS were improved more obviously in the observation group.2 patients in the observation group appeared elevated transaminase and then reduced after the discontinuation of atorvastatin calcium.1 case in the control group appeared liver and kidney function damage. ConclusionAtorvastatin calcium combined with extended release nifedipine tablets has good effect in the treatment of mild to moderate hypertension with left ventricular hypertrophy,and has no obvious damage of liver and kidney.

关 键 词：轻中度高血压 左室肥厚 阿托伐他汀钙 硝笨地平缓释片 

分 类 号：R544.1[医药卫生—心血管疾病] R589.2[医药卫生—内科学]