鞍山中心医院丙型肝炎病毒亚型的分布状态  

Distribution of Hepatitis C virus genotype in Anshan Central Hospital

作　　者：张艳红[1] 解莹[1] 谢晨[1] 刘文芝[1] 魏越[2] 

机构地区：[1]大连医科大学附属第二医院感染疾病科,辽宁大连116027 [2]鞍山市中心医院传染科,辽宁鞍山114001

出　　处：《大连医科大学学报》2015年第4期358-360,366,共4页Journal of Dalian Medical University

基　　金：辽宁省科技厅项目(2010225034)

摘　　要：目的了解鞍山地区丙型肝炎病毒(HCV)基因分型的情况。方法采用型特异性引物逆转录巢式PCR法对鞍山地区抗HCV和HCV RNA均阳性的患者共189例进行基因分型。结果在189份抗HCV和HCV RNA均阳性血清中基因型分别检测出了1b和2a型,未发现混合型感染,其中11份为阴性。结论鞍山地区基因型有1b型和2a型两种型,未发现其他亚型,1b型(53%)和2a型(47%)基本相等。Objective To investigate the distribution of HCV genotype in Anshan. Methods HCV genotype was determined by RT - nested - PCR in 189 cases of anti - HCV and HCV RNA positive patients in Anshan. Results In the serum of the 189 anti -HCV and HCV RNA positive patients, lb and 2a were detected. No mixed genotype was found. 11 cases were negative. Conclusion There are only two HCV genotypes, lb and 2a, found in Anshan. They have almost equal distribu- tion with 53% lb and 47% 2a, respectively.

关 键 词：丙型肝炎病毒 基因型 亚型 型特异性引物 逆转录巢式PCR法 

分 类 号：R512.63[医药卫生—内科学]