有机阳离子转运体2(808G>T)基因多态性对健康受试者体内盐酸二甲双胍药动学影响的Meta分析  

Effect of Organic Cation Transporter 2(808G>T) Gene Polymorphism on Metformin Hydrochloride Pharmacokinetics in vivo of Health Volunteer:a Meta-analysis

作　　者：宋佳[1] 吴玉波[1] 刘利龙 吴禹蒙[1] 张婷婷[1] 王叶新[1] 

机构地区：[1]哈尔滨医科大学附属第四医院药学部,哈尔滨150001

出　　处：《中国药房》2015年第24期3386-3389,共4页China Pharmacy

摘　　要：目的:系统评价有机阳离子转运体2[(OCT2)808G>T]基因多态性对健康受试者体内盐酸二甲双胍药动学的影响,以为临床用药提供循证参考。方法:计算机检索Pub Med、EMBase、西文生物医学期刊文献数据库、中国期刊全文数据库、中文科技期刊数据库、万方数据库,收集(OCT2)808G>T基因多态性对健康受试者体内盐酸二甲双胍药动学影响的相关研究,采用Rev Man 5.1统计软件进行Meta分析。结果:共纳入5项回顾性研究,合计172例受试者,基因检测结果为GT型、TT型、GG型。Meta分析结果表明,与GT型基因相比较,TT型会延长盐酸二甲双胍的半衰期;与TT型基因相比较,GG型会增大盐酸二甲双胍的峰浓度。而(OCT2)808G>T基因多态性不会对肾脏清除率、肌酐清除率和药-时曲线下面积造成影响。结论:(OCT2)808G>T基因多态性对健康受试者体内盐酸二甲双胍半衰期和峰浓度有一定影响,对肾脏清除率、肌酐清除率和药-时曲线下面积没有影响。受纳入研究方法学的限制,该结论尚需大样本、高质量的研究进一步验证。OBJECTIVE： To systematically review the effect of organic cation transporter 2 [（OCT2）808G？〉T] gene polymorphism on the metformin hydrochloride pharmacokinetics in vivo, and to provide evidence-based reference for clinical medication. METHODS： Retrieved from PubMed, EMBase, Foreign Medical Journey Service, CJFD, VIP database and Wanfang database, related studies about the effect of （OCT2）808G〉T gene polymorphism on the metformin hydrochloride pharmacokinetics in vivo were collected, and Meta-analysis was performed by using Rev Man 5.1 statistics software. RESULTS： A total of 5 retrospective studies were included, involving 172 patients. The result of gene type was type GT,type TT and type GG. Results of Meta-analysis showed, compared with type GT volunteers, type TT could prolong the half-time period of metformin hydrochloride; compared with type TT, type GG could increase the peak concentration. However, （OCT2）808G〉T gene polymorphism had no effects on the renal clearance rate, creatinine clearance rate and area under the drug-time curve. CONCLUSIONS： （OCT2）808G〉T gene poly- morphism has certain effect on the half-time period and peak concentration of metformin hydrochloride in vivo of health volunteer, and has no effect on the renal clearance rate, creatinine clearance rate and area under the drug-time curve. Due to the limit of re- search methodological quality, large-scale and high quality studies are required for further validation of the conclusions.

关 键 词：糖尿病 二甲双胍 基因多态性 有机阳离子转运体2 

分 类 号：R969.1[医药卫生—药理学]