复方灵芝孢子精油软胶囊抗疲劳增强免疫力作用研究  

Effect of Compound Ganoderma Lucidum Spore Oil Soft Capsule on Antifatigue and Immunopotentiation

作　　者：鲍蕾蕾[1] 杨帆[2] 陈海飞[1] 卞俊[1] 唐大海[3] 

机构地区：[1]中国人民解放军第411医院药学科,上海200434 [2]中国人民解放军总政治部白石桥干管局青年湖干休点,北京100011 [3]中国人民解放军第411医院检验科,上海200434

出　　处：《中国药业》2015年第16期14-16,共3页China Pharmaceuticals

基　　金：全军医学科学技术研究"十二五"面上课题;项目编号:CWS11J178;上海市卫生局青年基金项目;项目编号:2009Y118

摘　　要：目的研究复方灵芝孢子精油软胶囊抗疲劳、增强免疫力的药理作用。方法将昆明种小鼠随机分为5组,分别为复方灵芝孢子精油软胶囊(FFLZB)低、中、高[385,770,1 540 mg/(kg·d)]剂量组、对照药红参醇提物组、空白对照组,灌胃给药14 d后考察各组小鼠爬杆时间及爬杆后血清肌酸激酶(CK)、三磷酸腺苷(ATP)水平,同时采用免疫脏器指数法、碳粒廓清法、足趾增厚法测定迟发型变态反应(DTH),考察FFLZB对小鼠免疫功能的影响。结果高、中、低剂量FFLZB能不同程度地延长小鼠爬杆时间,高、中剂量能显著提高小鼠爬杆后血清ATP水平,仅低剂量能使爬杆后的小鼠血清CK酶水平显著提高;与空白对照组相比,FFLZB高、中、低3个剂量能不同程度地抑制小鼠免疫器官脏器指数的下降,提高碳粒廓清指数水平及24,48 h迟发型变态反应程度。结论复方灵芝孢子精油软胶囊具有抗疲劳及增强免疫力作用,是一种有效的抗疲劳复方中药制剂。Objective To researcb tbe pbarmacological effect of antifatigue and immunopotentiation of Compound Ganoderma Lucidum Spore Oil Soft Capsule. Methods Kunming mice were radomly devided into five groups：tbe low,middle and bigb FFLZB doses groups [ 385,770,1 540 mg/ （ kg＆#183;d）] ,control red gingseng etbanol extract group and blank control group. Tbe pole-climbing time,serum cre-atinine kinase（CK）and adenosine tripbospbate（ATP）contents on 14 d after medication gavage were detected. At tbe same time tbe immune organ index metbod,cleaning carbon particle metbod and digits tbickening metbod were adopted to detect delayed type bep-ersensitivity（DTH）for investigating tbe influence of CGOC on mice′s immune function. Results Tbe bigb,middle and low doses FFLZB groups could prolong tbe pole-climbing time in different degrees,tbe middle and bigb doses groups could significantly increase tbe serum ATP level after pole-climbing,only tbe low dose group could significantly increase serum CK level after pole-climbing;com-pared witb tbe blank control group,tbe bigb,middle and low FFLZB doses groups could inbibit tbe decrease of mice immune organ in-dex in different degrees,increased tbe level of leaning carbon particles and 24,48 b DTH degree. Conclusion FFLZB bas tbe an-tifatigue and immunopotentiation effect and is a compound Cbinese medicine preparation for effective antifatigue.

关 键 词：抗疲劳 免疫功能 灵芝孢子精油 小鼠 

分 类 号：R285.5[医药卫生—中药学] R286[医药卫生—中医学]