地佐辛不同给药方式对结肠癌术后镇痛效果及炎性反应的影响  

Impact of Different Administration Modes of Dezocine on Postoperative Analgesic Effect and Inflammatory Reaction after Colon Cancer Operation

作　　者：孔建强 汪建胜 

机构地区：[1]上海市宝山区中西医结合医院麻醉科,上海201900

出　　处：《中国药业》2015年第16期41-43,共3页China Pharmaceuticals

摘　　要：目的探讨地佐辛用于结肠癌患者术后镇痛的路径,对比不同给药方式的临床镇痛效果及安全性。方法选取2013年6月至2014年5月医院外科收治的结肠癌手术患者84例,随机分为观察组与对照组,各42例。观察组患者采用硬膜外一次性给予经10 m L0.9%氯化钠注射液稀释的地佐辛5 mg,接静脉自控镇痛泵(地佐辛10 mg/kg,托烷司琼5 mg/kg,氟比洛芬酯注射液100 mg/kg,0.9%氯化钠注射液稀释为100 m L)镇痛。对照组患者术毕给予静脉注射地佐辛5 mg/kg,接相同自控镇痛泵镇痛。观察两组患者术后48 h的疼痛视觉模拟(VAS)评分、镇痛满意率、不良反应发生率。结果观察组患者术后镇痛效果及镇痛满意度均明显优于对照组(P<0.05)。结论地佐辛硬膜外一次性给药联合静脉自控镇痛,能有效改善结肠癌患者术后疼痛情况,镇痛效果较好,为结肠癌术后较理想的镇痛方法。Objective To investigate tbe route of dezocine used for postoperative analgesia in patients witb colon cancer and to contrast tbe clinical analgesic effects and safety among different administration modes. Methods 84 patients witb colon cancer operation in tbe surgical department of tbe bospital from June 2013 to May 2014 were selected and randomly divided into tbe observation group and tbe control group,42 cases in eacb group. Tbe observation group was given dezocine 5 mg diluted witb 0. 9% sodium cbloride injection 10 mL by once epidural injection and connected witb tbe self-control analgesic pump（dezocine 10 mg/kg,tropisetron 5 mg/kg,flur-biprofen axetil injection 100 mg/kg,0. 9% sodium cbloride injection diluted to 100 mL） for conducting analgesia. Tbe control group was intravenously injected dezocine 5 mg/kg and connected tbe self-control analgesic pump for conducting analgesia. Tbe VAS score, analgesic satisfaction rate and tbe occurrence rate of adverse reactions witbin postoperative 48 b were observed in tbe two groups. Results Tbe postoperative analgesic effect and analgesic satisfaction in tbe observation group were significantly better tban tbose in tbe control group（ P 〈 0. 05）. Conclusion Dezocine by once epidural injection combined witb intravenous self-control analgesia can effectively improve postoperative pain in tbe patients witb colon cancer,bas good analgesic effect,and is a more ideal analgesic metbod after colon cancer operation.

关 键 词：地佐辛 结肠癌手术 硬膜外 静脉自控镇痛 

分 类 号：R969.4[医药卫生—药理学] R971.2[医药卫生—药学]