糖脉康对2型糖尿病患者肠促胰岛素与胰岛素抵抗的影响  

Influence of Tangmaikang Granule on GLP- 1 and Insulin Resistance in Patients with Type2 Diabetes

作　　者：李忠文[1] 陈重[1] 裴剑浩[1] 李泽 陈红梅[1] 

机构地区：[1]广东省人民医院.广东医学科学院,广东广州510120 [2]广东省广州市第二人民医院,广东广州510150

出　　处：《中国药业》2015年第16期58-60,共3页China Pharmaceuticals

基　　金：广东省中医药局课题;项目编号:2009115;广东省卫生厅课题;项目编号:A2010027

摘　　要：目的研究糖脉康颗粒对新诊断2型糖尿病患者的肠促胰岛素(GLP-1)与胰岛素抵抗的影响。方法选取医院收治的患者31例,均进行饮食、运动治疗,并给予糖脉康颗粒(口服,每次5 g,每日3次),每2周为1个疗程,治疗2个疗程。观察并记录患者治疗前后混合餐耐量试验(MMTT)情况,对各类症状进行分析评分;收集患者MMTT中0,15,30,60,90,120 min血标本,检验并记录血糖、GLP-1、胰岛素和C-肽变化情况;记录患者治疗前后血脂、血液流变学各项指标变化及不良反应发生情况。结果治疗后,患者临床症状评分明显降低(P<0.05或P<0.01);GLP-1在60 min时增加(P<0.05),其他时间段则无差异(P>0.05),胰岛素、C-肽无明显变化(P>0.05);血糖在30,60,90,120 min明显降低(P<0.05),且未出现低血糖,无其他不良反应。结论糖脉康颗粒可有效改善新诊断2型糖尿病患者的临床症状,改善胰岛素抵抗,提高胰岛素效率,对GLP-1无明显促进作用,安全性高,值得临床推广。Objective To study tbe influence of Tangmaikang granule on GLP-1 and insulin resistance in newly diagnosed type 2 dia-betic patients. Methods Totally 31 patients were selected and treated by diet,exercise,and Tangmaikang granule（oral,5 g/time,3 times/d）. Tbe course of treatment was two weeks,and tbe treatment lasted for two courses. To observe and record tbe MMTT of tbe pa-tients before and after tbe treatment,analyze and evaluate tbe symptoms scores. Tbe blood samples at 0,15,30,60,90,120 min during MMTT were collected,and tbe cbanges of blood glucose,insulin and C-peptide were examined and recorded. Tbe cbanges of blood lipids（TG,LDL-C,TC,HDL-C）,bemorbeology and adverse reactions were recorded before and after treatment. Results Compared witb before treatment,tbe clinical symptom score was significantly lower（ P 〈 0. 05 or P 〈 0. 01）;GLP-1 increased at 60 min（ P 〈0. 05）,and tbere was no difference at otber time points（ P 〉 0. 05）;tbe insulin and C-peptides bad no significant cbange（ P〉0. 05）;tbe glucose levels of blood glucose at 30,60,90,120 min were significantly decreased（ P 〈 0. 05）,and tbere were no bypo-glycemia and otber adverse reactions. Conclusion Tangmaikang can granule effectively improve tbe clinical symptoms of tbe newly diag-nosed type 2 diabetic patients,improve insulin resistance and tbe efficiency of insulin,bas no obvious promoting effect on GLP-1. It is safe and deserves to be clinically promoted.

关 键 词：2型糖尿病 糖脉康颗粒 胰岛素 肠促胰岛素 

分 类 号：R285.6[医药卫生—中药学] R286[医药卫生—中医学]