右美托咪定联合可视喉镜用于气管插管老年患者63例疗效评价  

Application of Dexmedetomidine Combined with UE- HC Glidescope in Elderly Patients with General Anesthesia Endotracheal Intubation in 63 Cases

作　　者：万向学 郑秋艳[1] 

机构地区：[1]河北省唐山市人民医院,河北唐山063000

出　　处：《中国药业》2015年第16期67-69,共3页China Pharmaceuticals

摘　　要：目的观察右美托咪定联合UE-HC可视喉镜用于全身麻醉(简称全麻)气管插管老年患者的临床疗效。方法选择医院2013年收治的行全麻气管插管治疗老年患者126例,按随机数字表法分为观察组和对照组,各63例。气管插管前,观察组静脉注射右美托咪定,对照组静脉注射等量0.9%氯化钠注射液,观察两组患者在进入手术室平静后(T0),麻醉诱导时(T1),气管插管时(T2)、插管后3 min(T3)、拔管时(T4)、拔管后3 min(T5)时心率(HR)、舒张压(DBP)及收缩压(SBP)等指标的变化。结果观察组患者的HR及DBP,SBP在T1及以后的各个时间点均显著低于对照组(P<0.05);观察组呛咳、躁动、恶心等不良反应显著少于对照组(P<0.05);观察组患者在气管插管过程中未出现呼吸抑制症状,拔管后安静入睡率为63.49%,显著高于对照组的19.05%(P<0.05)。结论右美托咪定结合UE-HC可视喉镜用于全麻气管插管老年患者,可有效避免心动过速,提高血流动力学稳定性,无呼吸抑制,镇静效果显著,且可减少呛咳等不良反应的发生率,值得临床推广。Objective To observe tbe clinical effect of dexmedetomidine combined witb UE-HC glidescope in elderly patients witb gen-eral anestbesia endotracbeal intubation. Methods 126 patients witb general anestbesia endotracbeal intubation in tbe bospital during 2013 were selected and randomly divided into tbe observation group and tbe control group according to tbe random number table,63 cases in eacb group. Tbe observation group was intravenously injected by dexmedetomidine before endotracbeal intubation,wbile tbe con-trol group was intravenously injected by tbe same amount of 0. 9% sodium cbloride injection before endotracbeal intubation. Tbe cbanges of HR,DBP,SBP at calmness after entering operation room（T0）,anestbesia induction（T1）,endotracbeal intubation（T2）,at 3 min after en-dotracbeal intubation（T3）,extubation（T4） and at 3 min after extubation（T5） were observed in tbe two groups. Results HR,DBP and SBP at various time points after anestbesia induction（T1） in tbe observation group were significantly lower tban tbose in tbe control group（ P 〈 0. 05）. Tbe adverse reactions of bucking,restlessness and nausea occurred in tbe observation group were significantly less tban tbose in tbe control group（ P 〈 0. 05）;tbe observation group bad no respiratory depression symptoms in tbe course of intubation, tbe quiet sleep rate after extubation in tbe observation group was 63. 49%,wbicb was significantly bigber tban 19. 05% in tbe control group（ P 〈 0. 05）. Conclusion Tbe application of dexmedetomidine combined witb UE-HC glidescope in elderly patients witb general anestbesia endotracbeal intubation can effectively avoid tacbycardia,improve tbe bemodynamic stability,bas no respiratory depression witb significantly sedative effect,can reduce tbe incidence of adverse reactions sucb as bucking,wbicb is wortby of clinical promotion.

关 键 词：右美托咪定 可视喉镜 全身麻醉 气管插管 

分 类 号：R969.4[医药卫生—药理学] R971.2[医药卫生—药学]