pH响应型聚合物前药的研究进展  

Advances in pH-responsive polymeric prodrugs

作　　者：李宁[1] 张恒[2] 刘晓燕[1] 

机构地区：[1]济南军区总医院干部三科B区,山东济南250031 [2]滨州医学院附属医院药学部,山东滨州256603

出　　处：《中国新药与临床杂志》2015年第8期578-584,共7页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：pH响应型聚合物前药作为新兴的递药系统具有良好的应用前景。它能够主动靶向于肿瘤细胞,实现细胞内药物的可控释放,增强药物疗效并降低其不良反应。本文主要讨论了pH响应型聚合物前药的体内作用机制,并结合具体的实例,以聚合物载体的结构为分类标准,对pH响应型聚合物前药的应用进行了综述。pH- responsive polymeric prodrugs as a novel drug delivery system hold great promise ior clinical application. They could actively target to tumor ceils, achieve controlled drug release in intracellular conditions, enhance the therapeutic efficacy and reduce side effects. In the article, the action mechanism of pH- responsive polymeric prodrugs were discussed. Additionally, using selected examples from the literature, prodrug molecules with different chemical properties and architectures were presented, providing a preliminary overview on pH-responsive polymeric prodrugs.

关 键 词：PH响应 聚合物 药物前体 抗肿瘤药 内环境稳定 

分 类 号：R94[医药卫生—药剂学]