肝细胞生长因子与男性生殖  

Hepatocyte growth factor and male reproduction

作　　者：周兴[1] 何清湖[2] 

机构地区：[1]湖南中医药大学第一附属医院男科,湖南长沙410007 [2]湖南中医药大学中西医结合学院,湖南长沙410208

出　　处：《中华男科学杂志》2015年第8期747-752,共6页National Journal of Andrology

基　　金：国家自然科学青年基金(81202706)~~

摘　　要：肝细胞生长因子(HGF)是一种多效性生长因子,通过与受体c-Met结合后发挥多种生物学效应。本文阐述其生物学特性,并着重强调其与男性生殖的相关性,包括HGF具有促胚胎期睾丸发育、睾丸生精细胞和精子发生、睾丸间质细胞睾酮合成等作用,希望HGF能在男性迟发性性腺功能减退、少弱精子症等男科疾病的治疗方面,提供新的思路与方法,只是目前尚缺乏相关的临床研究。The hepatocyte growth factor （HGF） is a multifunctional growth factor, which produces multiple biological effects by binding to the e-Met aceeptor. This article reviews the biological properties of HGF, particularly those correlated with male reproduction, including its abilities to promote testis embryonic development, spermatogenesis, and testosterone synthesis of Leydig cells. HGF may provide a new insight into the treatment of male hypogonadism and infertility.

关 键 词：肝细胞生长因子 C-MET 男性生殖 

分 类 号：R698[医药卫生—泌尿科学]