β_2M-蛋白在周围动脉疾病中的诊断意义  

Diagnostic significance of β_2-microglobulin for peripheral arterial disease

作　　者：余泽洪[1] 李华 陈林祥[1] 李瑞庆[1] 钱艳红[1] 王晓霞[1] 叶伟云 冼伟进[1] 

机构地区：[1]广东省江门市人民医院,广东江门529050 [2]广东省江门市江海区中西医结合医院,广东江门529050

出　　处：《心血管病防治知识（学术版）》2015年第8期108-110,共3页Prevention and Treatment of Cardiovascular Disease

基　　金：江门市科学技术委员会重点科研科题

摘　　要：目的探讨β2-微球蛋白(β2M)对周围动脉疾病的(PAD)的早期诊断意义。方法本文共收集:PDA[踝臂指数(ABI〈0.9)]患者63例,PDA组与ABI正常,无PDA临床表现的正常组73例,分别检测β2M,高敏C反应蛋白(hs CRP),对两组临床资料进行对比分析。结果 PDA组β2M及hs CRP值显著差高于对照组(P<0.05),但PDA组β2M更显著高于对照组(P<0.001)。结论 PDA组患者β2M值升高,是PDA的相关因素,此一研究结果认为β2M值升高亦为心血管危险因素有助于PDA的早期诊断。Objective To investigate the significance of β2-microglobulin （β2M） in the early diagnosis of peripheral arterial disease （PAD）. Methods This study included 63 cases of PAD [ankle brachial index （ABI） 〈0.9） and 73 controls with normal ABI and with no clinical manifestations of PAD. The levels of β2M and high-sensitivity C- reactive protein （hs-CRP） were determined for both groups. And the clinical data in the two groups were compared and analyzed. Results The levels of β2M and hs-CRP in the PAD group were significantly higher than those in the control group （P〈0.05）, and the β2M level in the PAD group was extremely higher than that in the control group （P〈0.001）. Conclusion The β2M level in PAD patients increases, so β2M is a factor associated with PAD. The results of this study show that the elevation of β2M level is a factor for cardiovascular risk, which can contribute to early diagnosis of PAD.

关 键 词：Β2微球蛋白 超敏C反应蛋白 周围动脉疾病 

分 类 号：R543[医药卫生—心血管疾病]