人乳头瘤病毒感染及其免疫学进展  

Human papillomavirus infection and its immunology progress

作　　者：包振宇[1] 邹先彪[2] 张云杰[2] 

机构地区：[1]解放军医学院,北京100853 [2]解放军总医院第一附属医院皮肤科

出　　处：《实用皮肤病学杂志》2015年第4期284-286,290,共4页Journal of Practical Dermatology

基　　金：解放军总医院"百项优势"基金

摘　　要：人乳头瘤病毒(HPV)感染引起人皮肤和黏膜的多种良、恶性病变,如尖锐湿疣、宫颈上皮内瘤样变及宫颈癌等。HPV感染后可刺激宿主免疫系统(特异性免疫和非特异性免疫)产生一定的免疫应答;HPV亦通过多种免疫逃逸机制逃避宿主免疫系统的监视与清除。HPV与宿主免疫系统之间的相互作用决定了HPV感染后不同的临床表现(临床无症状或病变持续存在甚至发生癌变)。该文综述了HPV感染后宿主免疫反应及HPV免疫逃逸机制的研究进展。Human papillomavirus （HPV） infection can cause a variety of benign and malignant lesions of skin and mucosa, such as condyloma acuminatum, cervical intraepithelial neoplasia （CIN） and cervical cancer. HPV infection can stimulate the host’s immune system （specific immunity and nonspecific immunity） that responses to some certain. HPV also can evade the surveillance and clearing of the host’s immune system through a variety of immune escape mechanisms. The interaction between HPV and the host immune system determines the different clinical manifestations of HPV infection （without clinical symptoms, lesions persist or even cancer）. This paper will review the research progress of host’s immune response and immune escape mechanism after HPV infection.

关 键 词：人乳头瘤病毒 免疫 特异性 免疫 非特异性 免疫逃逸 

分 类 号：R392[医药卫生—免疫学]