碘克沙醇用于脑血管造影及支架植入安全性观察  

Iodixanol used for cerebral angiography and stent implantation: observation of its safety

作　　者：姜敏霞[1] 季中[1] 周理余[1] 陈旭高[1] 

机构地区：[1]浙江省丽水市人民医院放射科,323900

出　　处：《介入放射学杂志》2015年第8期720-722,共3页Journal of Interventional Radiology

基　　金：浙江丽水市科技计划项目(2013ZC012)

摘　　要：目的观察对比剂碘克沙醇用于脑血管造影及支架植入术时的安全性,了解碘克沙醇所致对比剂肾病、急性不良反应及迟发性不良反应的发生率。方法收集2013年1月至2014年12月采用碘克沙醇行脑血管造影或支架植入术患者99例,术前1 d及术后1、3 d测定患者血清肌酐(SCr)值及血尿素氮(BUN)值,并严密观察患者使用碘克沙醇期间的不良反应发生情况。结果患者术后血清SCr及BUN平均值较术前有所下降,未发生对比剂肾病。发生轻微急性不良反应3例(3.0%)、迟发性不良反应7例(7.0%)。结论碘克沙醇用于脑血管造影及支架植入术对患者肾功能基本无影响,但需注意急性及迟发性不良反应。Objective To evaluate the safety of iodixanol used for cerebral angiography and stent implantation, and to investigate the incidence of contrast-induced nephropathy, acute and delayed adverse reactions. Methods During the period from January 2013 to December 2014 at authors＇ hospital, cerebral angiography or stent implantation, using iodixanol as contrast agent, was performed in a total of 99 patients. Serum creatinine （SCr） and blood urea nitrogen （BUN） levels were determined one day before as well as one and 3 days after the procedure. After the procedure, the patients were kept under close observation for iodixanol-related adverse reactions. The results were analyzed. Results The postoperative mean SCr and BUN levels were strikingly lower than the preoperative ones. No contrast-induced nephropathy occurred. Mild acute adverse reaction was seen in 3 cases （3.0%）, and delayed adverse reaction was observed in 7 cases （7.0%）. Conclusion In performing cerebral angiography and stent implantation, the use of iodixanol has no obvious effect on the renal function, but attention should be paid to the acute and delayed adverse reactions.

关 键 词：脑血管造影 支架植入术 对比剂 碘克沙醇 

分 类 号：R651.1[医药卫生—外科学]