干燥综合征继发结节性肺淀粉样物沉积症临床病理特征  

Clinical and pathological analysis of pulmonary nodulous amyloidosis secondary to Sjgren's syndrome

作　　者：杨朝晖[1] 何燕[2] 陈辉[2] 魏雪[2] 周晓军[2] 沈勤[2] 

机构地区：[1]浙江省台州市中心医院病理科 [2]南京军区南京总医院病理科,南京210002

出　　处：《诊断病理学杂志》2015年第8期489-492,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的深入认识干燥综合征继发结节性肺淀粉样物沉积症的临床特征、影像学表现和病理学改变。方法报道干燥综合征继发结节性肺淀粉样物沉积症1例,分析临床特征、观察影像学和病理改变,结合相关文献进行探讨。结果患者既往干燥综合征病史7年,无肺部异常不适。CT提示右肺中叶类圆形软组织密度影,边缘欠光整,见少许毛刺影。病理学检查示右肺中叶组织内见大量致密无结构嗜酸性物质沉积,刚果红染色呈(+),结节周边淋巴浆细胞聚集。结论干燥综合征继发结节性肺淀粉样物沉积症非常罕见,临床表现无特异性,容易误诊,确诊依赖病理学检查,避免过度治疗。Objective To discuss the clinical features,imageology and pathology of pulmonary nodulous amyloidosis secondary to Sjogren ＇s syndrome. Methods Features of a case of pulmonary nodular amyloidosis with Sjogren ＇s syndrome were summarized while referring literature review. Results The patient had Sjogren＇s syndrome for seven years,without pulmonary abnormalities. The computer tomography displayed nodule density patching shadow,with focally unclear margins and spicucation. Inspection showed a large amount of homogeneous patchy structureless substance which was positive to Congo red staining under epithelial cells of pulmonary mucosa. Pulmonary nodulous amyloidosis had an indolent course,and only a few patients might suffer from a recurrence or became lymphadenoma. Conclusion Pulmonary nodulous amyloidosis secondary to Sjogren＇s syndrome is very rare. Tracheobronchial amyloidosis has no special clinical characteristics and is apt to be misdiagnosed. Pathologic examination is the only approach to diangosis.

关 键 词：淀粉样变 结节性 肺 干燥综合征 

分 类 号：R442.8[医药卫生—诊断学]