单纯形网格法优化灯盏花素微乳处方及其理化性质考察  

Optimization of microemulsion containing breviscapine with method of simplex lattice and its physicochemical properties

作　　者：黄庆德[1] 姚娜[1] 胡建萍[1] 陈雪[1] 

机构地区：[1]福建中医药大学药学院,福建福州350122

出　　处：《中国医院药学杂志》2015年第15期1401-1405,共5页Chinese Journal of Hospital Pharmacy

基　　金：福建省科技计划重点项目(编号:2012Y0042);福建省科技计划项目(编号:2010Y2004);福建省教育厅A类科技项目(编号:JA11130)

摘　　要：目的:优化灯盏花素微乳处方,并对其理化性质进行考察。方法:绘制伪三元相图,确定各相的比例,以载药量、粒径及粒径分布为评价指标,采用单纯形网格法优化微乳处方,并考察优化微乳的黏度、pH、电导率、粒径分布等理化性质。结果:选用Labrafil M1944cs(10%),Kolliphor RH40(30%),PEG400(60%)制备微乳,所得微乳平均粒径约为27 nm,粒径分布(PDI)平均值为0.198。响应方程预测的指标值与实测值相近。所得优化微乳性质稳定。结论:单纯形网格法能够客观的优化微乳处方,优化所得微乳载药量高,粒径小,分布均匀。所建立的响应方程能够准确的对微乳的载药量、粒径及粒径分布进行预测。OBJECTIVE To study the optimization and the physicochemical properties of breviscapine microemulsion. METHODS Pseudo-tertiary phase diagrams were prepared to obtain the concentration ratio of components of the microemulsion. Using simplex lattice method with drug loading, particle size and distribution as the evaluation indexes. The formulation of microemulsion was optimized and the physicochemical properties including viscosity, pH, conductivity and particle size distribution were examined. RESULTS The formulation is 10% Labrafil M 1944cs,30% Kolliphor RH40, 60% PEG400. The average particle size was 27 nm,PDI was 0. 198, the experiment values from simplex lattice system were close to that of the pre- dicted value from the equation. The property of optimized microemulsion showed to be stable behavior. CONCLUSION Simplex lattice is objectively to optimize the formulation of microemulsion. The microemulsion of optimization is high drug loading, small particle size, uniform distribution. The optimization equation can predict drug loading, particle size and distribution of microemulsion system.

关 键 词：灯盏花素 微乳 单纯形网格法 

分 类 号：R943[医药卫生—药剂学]