慢性心力衰竭患者血浆NGAL水平变化及与NT-proBNP相关性的研究  

Relationship of neutrophil gelatinase associated lipocalin and N-terminal pro-B-type natriuretic peptide in chronic heart failure

作　　者：陈薇[1] 胡汉宁[1] 黎安玲[1] 刘艳源[1] 

机构地区：[1]武汉大学中南医院检验科,武汉430071

出　　处：《临床心血管病杂志》2015年第8期864-867,共4页Journal of Clinical Cardiology

基　　金：湖北省自然科学基金(No:2012FFB04411)

摘　　要：目的:观察97例慢性充血性心力衰竭(CHF)患者血浆中性粒细胞明胶酶相关脂质运载蛋白(NGAL)和N-末端B型脑钠肽前体(NT-proBNP)等指标水平变化,并探讨两者间的相关关系。方法:收集97例CHF患者(CHF组)的临床资料,进行回顾性分析。同期年龄相同体检为健康者50例作为对照组。比较分析CHF组与对照组血浆中NGAL、NT-proBNP,尿素氮(BUN)、肌酐(Cr)、肾小球滤过率(eGFR)以及左心功能指标左心室射血分数(LVEF)。结果:CHF组患者血NGAL、血NT-proBNP、BUN和Cr水平明显高于对照组(均P<0.05),而LVEF、eGFR低于对照组(P<0.05),血NGAL、NT-proBNP在各组中水平依次是NYHA-Ⅳ级>NYHA-Ⅲ级>NYHA-Ⅱ级>NYHA-Ⅰ级,各级间差异均有统计学意义(P<0.05)。CHF组患者血清NGAL与NT-proBNP呈正相关(r=0.79,P<0.05),LVEF与血浆NGAL、NT-proBNP水平呈负相关(r=-0.36,P<0.05;r=-0.39,P<0.05)。结论:CHF组患者血浆NGAL和NT-proBNP水平升高与心力衰竭、肾损伤的发展进程有关。Objective.. To observe the changes of concentrations of NGAL and NT-proBNP in patients with chronic heart failure and investigate the relationship between these two testing items. Method：The clinical data of 97 patients with CHF were retrospectively analyzed. A total of 50 patients in the same age were selected as health control group who did health examination. Plasma NGAL,NT-proBNP levels, BUN, Cr, eGFR and LVEF were compared between study group and control group using statistical analysis, P〈0.05 means the difference is statis- tical significant. Result ： Serum NGAL, NT-proBNP, BUN and Cr levels were higher in patients with CHF than control group（P〈0.05）, while eGFR and LVEFwere lower in study group than control group（P〈0.05）. Analy- sis of variance of blood NGAL level and NT-proBNP level in each group were NYHA-IV grade〉 NYHA-Ⅲ grade 〉 NYHA-Ⅱ grade〉 NYHA-I grade, there was statistically significant difference at all levels. Serum NGAL levels were positively related to NT-proBNP （r=0.79, P〈0. 05） and LVEF levels were negatively related to NGAL and NT-proBNP（r=- 0.36, P〈0.05 ; r= - 0.39, P〈0.05）. Conclusion.. The development of heart failure and renal injury was closely related to the increase of NGAL and NT-proBNP levels in CHF patients.

关 键 词：慢性充血性心力衰竭 中性粒细胞明胶酶相关脂质运载蛋白 N-末端B型脑钠肽前体 肾功能损伤 

分 类 号：R541.6[医药卫生—心血管疾病]