不停跳冠脉旁路分流术后血清胱抑素C水平与冠脉病变的关系  

Relationship between serum cystatin C level and coronary artery lesion after off-pump coronary artery bypass grafting

作　　者：周子凡[1] 万居易[2] 李温斌[1] 

机构地区：[1]北京安贞医院心脏外科,北京市100029 [2]泸州医学院附属医院心脏外科

出　　处：《心血管康复医学杂志》2015年第4期382-385,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的：观察接受不停跳冠脉旁路分流术（OPCABG）患者术后血清胱抑素C（Cys C）水平,探讨其与冠状动脉病变的关系。方法：选择2013年8月-2013年11月在我院心外科行OPCABG患者321例,按照病变支数分为单支组（11例）、双支组（33例）和多支组（277例）,采用双抗酶联免疫吸附法（ELISA）测定术后患者血清Cys C水平。结果：冠脉病变单支组、双支组和多支组CysC水平：OPCABG术前依次为（0.732±0.286）mg/L、（0.807±0.265）mg/L、（0.911±0.273）mg/L,3组间有显著差异（F=3.942,P=0.038）;术后依次为（0.616±0.198）mg/L、（0.607±0.201）mg/L、（0.646±0.166）mg/L 3组间无显著差异（F=0.493,P=0.617）,说明原先冠状动脉病变的程度与OPCABG术后CysC水平无明显关系（P〉0.05）。结论：不停跳冠状动脉搭桥术患者术后血清胱抑素C水平与原先冠状动脉病变程度无明显关系,即不停跳冠状动脉搭桥术对于冠心病患者是一有效治疗手段。Objective： To observe serum cystatin C （Cys C） level in patients before and after off-pump coronary artery bypass grafting （OPCABG）, and explore its relationship with coronary artery lesion. Methods.. A total of 321 patients, who received OPCABG in department of heart surgery of our hospital from Aug 2013 to Nov 2013, were selected. According to number of diseased coronary vessels, they were divided into single-vessel group （n = 11）,double-vessel group （n = 33） and multi-vessel group （n = 277）. Double antibody enzyme linked immunosorbent assay （ELISA） was used to measure serum Cys C level in all groups. Results： The Cys C levels in single-vessel group, double-vessel group, multi-vessel group before OPCABG were （0. 732 ± 0. 286） mg/L, （0. 807 ± 0. 265） mg/L, （0. 911 ±0. 273） mg/L respectively, there were significant difference （F= 3.942, P = 0. 038）; and after OPCABG were （0. 616 ± 0. 198） mg/L, （0. 607 ± 0. 201） mg/L, （0. 646 ± 0. 166） mg/L respectively , there were no signifi- cant difference （F = 0. 493, P = 0. 617）, namely there was no significant relationship between coronary artery disease extent and Cys C level after OPCABG, P〉0. 05. Conclusion： There is no significant relationship between original coronary artery disease extent and serum cystatin C level after off-pump coronary artery bypass grafting, namely off-pump coronary artery bypass grafting is an effective therapeutic measure for patients with coronary heart disease.

关 键 词：冠心病 半胱氨酸蛋白酶抑制物C 冠状动脉旁路移植术 非体外循环 

分 类 号：R541.75[医药卫生—心血管疾病]