促红细胞生成素联合铁剂对舒张性心衰并贫血患者的疗效  

Therapeutic effect of erythropoietin combined adjuvant iron treatment on patients with diastolic heart failure complicated anemia

作　　者：郭丽芬[1] 胡晓军[1] 晏凯利[1] 

机构地区：[1]湖北省新华医院心内科,湖北武汉430015

出　　处：《心血管康复医学杂志》2015年第4期421-425,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:观察促红细胞生成素(EPO)联合铁剂辅助治疗对舒张性心力衰竭(DHF)合并贫血患者心功能、运动能力及贫血的影响。方法:94例DHF合并贫血患者被随机分为:常规治疗组(46例)和联合治疗组(48例,在常规治疗基础上使用EPO联合铁剂治疗)。分别于治疗前及治疗6个月后进行6min步行试验,测定两组患者血红蛋白(Hb)、N末端B型利钠肽前体(NT-proBNP)水平,二尖瓣舒张早期峰速减速时间(DT)、舒张早期血流峰值(E)、舒张晚期血流峰值(A)、E/A值等指标,并进行比较。结果:与治疗前比较,治疗后两组患者NTproBNP、DT值显著下降,E/A比值、6min步行距离显著增加(P<0.05或<0.01);且治疗后与常规治疗组比较,联合治疗组NT-proBNP[(368.4±110.7)pg/ml比(239±89.7)pg/ml]、DT值[(257.5±73.4)ms比(208.9±59.1)ms]下降更显著,Hb水平[(83.3±9.2)g/L比(122.1±13.6)g/L]、E/A比值[(0.87±0.3)比(1.07±0.27)]、6min步行距离[(367.54±21.08)m比(438.63±20.35)m]显著增加(P均<0.05)。结论:促红细胞生成素联合铁剂治疗对舒张性心力衰竭合并贫血患者能更好地改善心功能及运动能力。Objective：To observe the influence of erythropoietin（EPO）combined adjuvant iron treatment on cardiac function,exercise capacity and anemia in patients with diastolic heart failure（DHF）complicated anemia.Methods：A total of 94 DHF ＋ anemia patients were randomly divided into routine treatment group（n=46）and combined treatment group（n=48,received EPO combined adjuvant iron treatment based on routine treatment）.Patients received 6min walking test,levels of hemoglobin（Hb）and N-terminal pro brain natriuretic peptide（NT-proBNP）,transmitral early diastolic peak velocity deceleration time（DT）,early diastolic peak flow velocity（E）,late diastolic peak flow velocity（A）and E/A etc.were measured and compared between two groups before and after six-month treatment.Results：Compared with before treatment,after treatment,NT-proBNP and DT significantly reduced,E/A and 6min walking distance significantly rose in both groups,P〈0.05or0.01;compared with routine treatment group after treatment,there were significant reductions in NT-proBNP level[（368.4±110.7）pg/ml vs.（239±89.7）pg/ml]and DT [（257.5±73.4）ms vs.（208.9±59.1）ms],and significant rise in Hb level[（83.3±9.2）g/L vs.（122.1±13.6）g/L],E/A [（0.87±0.3）vs.（1.07±0.27）]and 6min walking distance[（367.54±21.08）m vs.（438.63±20.35）m]in combined treatment group,P〈0.05 all.Conclusion：Erythropoietin combined iron treatment can better improve heart function and exercise capacity in patients with diastolic heart failure complicated anemia.

关 键 词：红细胞生成素 心力衰竭 舒张性 贫血 

分 类 号：R541.61[医药卫生—心血管疾病]