阿托伐他汀联合普罗布考对颈动脉粥样硬化斑块及血浆ox-LDL的影响  

The influence of Atorvastatin plus Probucol on carotid atherosclerotic plaque and plasma ox-LDL

作　　者：张冬萍 王慧红 

机构地区：[1]太原西山煤电集团总医院神经内科,山西太原030053

出　　处：《中国现代医生》2015年第19期100-102,共3页China Modern Doctor

摘　　要：目的研究阿托伐他汀联合普罗布考对颈动脉粥样硬化斑块及血浆ox-LDL的影响。方法将128例有颈动脉粥样硬化斑块的患者随机分为两组,每组64例;治疗组给予阿托伐他汀和普罗布考治疗,对照组只给予阿托伐他汀治疗。共观察52周,比较两组治疗前后颈动脉内膜斑块面积、血脂以及氧化型LDL(ox-LDL)水平的变化。结果最终纳入统计者122例,与对照组相比,治疗前两组患者颈动脉粥样硬化斑块面积、血脂水平、ox-LDL水平比较,差异均无统计学意义(P>0.05);而治疗52周后两组之间上述各项指标的比较差异均有统计学意义(P<0.01)。结论普罗布考联合阿托伐他汀治疗颈动脉粥样硬化斑块的疗效优于单纯阿托伐他汀治疗,可达到抗动脉粥样硬化、稳定斑块、抗氧化应激进而降低缺血性心脑血管病事件的目的。Objective To study the influence of Atorvastatin plus Probucol on carotid atherosclerotic plaque and plasma ox-LDL. Methods One hundred and twenty eight patients with carotid atherosclerotic plaque formation were randomly divided into two groups,64 cases in each group. Patients in the treatment group were treated with Atorvastatin plus Probucol, patients in the control group were treated with Atorvastatin alone. The plaque area,lipid and ox-LDL were measured before and 52 weeks after treatment. Results Finally 122 cases were included in the statistics.Before treat-ment there was no significant difference between two groups on carotid plaque area,lipid levels and ox-LDL level（P〉0.05）. But after 52 weeks treatment, the difference were remarkable（P〈0.01）. Conclusion Probucol combined with ator-vastatin in the treatment of carotid atherosclerotic plaque is better than pure atorvastatin treatment.Combination therapy can achieve the anti atherosclerosis plaque stability, anti oxidative stress, radical and lower ischemic cardio cerebral vascular disease objective.

关 键 词：阿托伐他汀 普罗布考 颈动脉粥样硬化 氧化型低密度脂蛋白 

分 类 号：R543.5[医药卫生—心血管疾病]