连云港农村45～75岁高血压人群血脂水平和肾小球高滤过关系的研究  

Study on relationship between lipid profiles and glomerular hyper-filtration in rural hypertensive patients aged 45-75 years in Lianyungang

作　　者：钟碧燕 汪月娟[1] 秦献辉[1] 李幼宝[1] 唐根富[2] 王滨燕[1] 臧桐华[2] 徐欣[1] 徐希平[1] 

机构地区：[1]南方医科大学南方医院器官衰竭防治国家重点实验室国家肾病临床研究中心,广东广州510515 [2]安徽医科大学生物医学研究所,安徽合肥230032

出　　处：《中华疾病控制杂志》2015年第8期798-802,810,共6页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81473052;81441091);"十二五"国家科技重大专项(2012ZX09101105);国家重点基础研究发展计划(2012CB517703)

摘　　要：目的 探索连云港农村45-75岁高血压人群甘油三酯（triglyceride,TG）、高密度脂蛋白胆固醇（high-density lipoprotein cholesterol,HDL-C）及甘油三酯-高密度脂蛋白胆固醇比值（triglyceride to high-density lipo-protein cholesterol,TG/HDL-C）和肾小球高滤过的关联性。方法 对2008-2009年参加中国连云港农村开展的中国脑卒中一级预防研究调查的17145例45-75岁原发性高血压患者进行调查,内容包括问卷调查、体格及实验室指标检测;采用CKD-EPI公式计算肾小球滤过率（estimated glomerula rfiltration rate,eGFR）水平;将大于eGFR残差值（调整了年龄和性别后）90%分位数定义为肾小球高滤过。结果 多因素Logistic回归结果显示,每增加一个单位Log-TG可使肾小球高滤过的发生风险增加4.45倍（95%CI：3.96-5.02）;同样,每增加一个单位Log-TG/HDL-C比值可使肾小球高滤过的发生风险增加3.10倍（95%CI：2.85-3.38）。HDL-C和肾小球高滤过在女性人群中呈负相关。结论 TG及TG/HDL-C比值和肾小球高滤过呈独立正相关关系,而HDL-C和肾小球高滤过仅在女性人群中呈负相关。Objective To investigate the relationship of triglyceride（ TG）,high-density lipoprotein cholesterol（ HDL-C）,or triglyceride to high-density lipoprotein cholesterol（ TG/HDL-C） ratio and glomerular hyper-filtration in a rural hypertensive population aged 45-75 years in Lianyungang. Methods 17 145 individuals with hypertension,aged 45-75 years from the China Stroke Primary Prevention Trial（ CSPPT） conducted in Lianyungang rural areas between 2008 and2009 were included in the final analysis. All participants had a questionnaire,physical exam and laboratory testing completed in the study. Estimated glomerular filtration rate（ e GFR） was calculated based on the equation of CKD-EPI. Renal hyper-filtration was defined as an absolute e GFR 90 th percentile after adjusting for sex and age. Results Multivariate adjusted Logistic regression models showed that,the log-TG was significantly associated with glomerular hyper-filtration,with odds ratio（ OR） of 4. 45（ 95% CI： 3. 96-5. 02）; similarly,the log-TG / HDL-C ratio was associated with an OR of 3. 10（ 95% CI： 2. 85-3. 38） for glomerular hyper-filtration; HDL-C was negatively associated with glomerular hyper-filtration after multivariate adjustment in females. Conclusions TG and TG / HDL-C ratio were positively associated with glomerular hyper-filtration,while HDL-C was negatively associated with glomerular hyper-filtration in females.

关 键 词：甘油三酯类 肾小球滤过率 高血压 

分 类 号：R181.2[医药卫生—流行病学]