(2-苯硫基乙基)丙二酸二乙酯的合成  

Synthesis of Diethyl [2-(phenylthio) ethyl]malonate

作　　者：于雅鑫 杨璐[2] 

机构地区：[1]吉林省药物研究院,吉林长春130061 [2]吉林省出入境检验检疫局,吉林长春130062

出　　处：《山东化工》2015年第16期1-2,6,共3页Shandong Chemical Industry

基　　金：吉林省省级公益性科研院所基本科研资助项目

摘　　要：以丙二酸二乙酯为原料,在强碱氢氧化铯作用下,与2-氯乙基苯硫醚反应得到(2-苯硫基乙基)丙二酸二乙酯。采用非质子溶剂N,N-二甲基甲酰胺作为反应溶剂,研究了各种反应条件对收率的影响,得到最佳条件为n(丙二酸二乙酯):n(氢氧化铯):n(2-氯乙基苯硫醚)=1.2:1:1,50℃反应4h,产物用1H NMR和MS进行了结构表征。Diethyl [ 2 -（phenylthio） ethyl] malonate was synthesized by the reaction of 2 -chloroethyl phenyl sulfide and diethyl malonate in the presence of cesium hydroxide by using N, N - Dimethylforrnamide as the reaction solvent at room temperature. The factors influencing the reaction yield were studied, the optimal reaction conditions were obtained when the molar ratios of diethyl malonate to cesium hydroxide to 2 - chloroethyl phenyl sulfide at 1.2：1 ： 1, with the reaction temperature at 50℃, and the reaction time for 5h, and the yield of product was 65%. The product was characterized by ^1H NMR and MS.

关 键 词：丙二酸二乙酯 氢氧化铯 (2-苯硫基乙基)丙二酸二乙酯 

分 类 号：O623.624.2[理学—有机化学]