正交试验法优选木香挥发油的提取工艺  

Optimization of Extraction Process Technology of Volatile oil from Radix Auckladiae by Orthogonal Design

作　　者：毛婷[1] 刘佳[1] 包保全[1] 任珊珊[1] 昌妍希 张屏[1,2] 

机构地区：[1]内蒙古医科大学药学院,内蒙古呼和浩特010110 [2]内蒙古民族大学蒙医药学院,内蒙古通辽028000

出　　处：《中国民族民间医药》2015年第16期24-25,共2页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：内蒙古自然科学基金重大项目"基血清化学和血清药理学的蒙药复方‘查干汤’药效物质基础研究"项目编号:2011ZD13;国家自然科学基金地区项目"基于循证医学理念和血清药物学方法的蒙医瘟疫热病经典方剂‘查干汤’抗流感药效物质基础及其代谢规律研究"项目编号:81460651

摘　　要：目的：优选出木香挥发油的最佳提取工艺。方法：采用水蒸气蒸馏法,以粉碎度、加水量、浸泡时间、提取时间为考察因素,以挥发油提取量为评价指标,应用正交试验设计法优选提取工艺。结果：木香挥发油的最佳提取工艺为将木香药材粉碎成1-3cm的粒度,加水7倍量,浸泡0h,蒸馏提取8h。该提取工艺稳定,三次提取的RSD为1.41%。结论：该工艺合理、可行、准确、可靠,为木香挥发油的提取工艺提供了实验依据。Objective To optimize the extraction technology of volatile oil from Radix Auckladiae. Methods The volatile oil of Ra- dix Auckladiae was extracted by technology of wet distillation, and orthogonal tests were used to optimize the extraction methods, using particle size, volume of solvent, immersion time and distillation time as investigation factors. Results The optimized extraction technology was that particle size rang from 1 cm to 3 cm, water volume 7 times of crud drug, immersion time was selected as Oh and distillation time 8h. The verification test showed that optimized technology derived more volatile oil than any of the orthogonal tests with high stability as RSD = 1.41%. Conclusion The optmized extraction technology is feasible, stable and practicable.

关 键 词：木香 挥发油 提取工艺 正交试验 水蒸气蒸馏法 

分 类 号：R284.2[医药卫生—中药学]