特异AT序列结合蛋白1和P504s在前列腺癌中的表达及临床意义  

Expressions of special AT-rich sequence-binding protein 1 and P504s in hunman prostatic carcinoma and their significance

作　　者：魏国华[1] 高志安 

机构地区：[1]辽宁医学院病理学教研室,辽宁锦州121000

出　　处：《中国现代医学杂志》2015年第23期32-34,共3页China Journal of Modern Medicine

摘　　要：目的探讨P504s及特异AT序列结合蛋白1(SATB1)基因在前列腺癌的表达,及其在前列腺癌发生、发展中的作用。方法应用免疫组织化学染色检测P504s及SATB1蛋白在60例前列腺癌和30例前列腺增生症组织中的表达。结果 SATB1在前列腺癌组织中的表达阳性率(78.3%)较前列腺增生组织(0.0%)明显升高,差异有统计学意义(P<0.05),SATB1的表达随着Gleason评分增加而升高(P<0.05)。P504s在前列腺癌组织中的阳性表达率(95.0%)远高于前列腺增生症组(0.0%)(P<0.05),但其在前列腺癌中的表达不会随着Gleason评分增加而升高(P>0.05)。结论 P504s和SATB1在前列腺癌中的高表达,结合形态学综合分析,可能有助于提高前列腺癌的诊断及鉴别诊断,而SATB1蛋白在前列腺癌组织中的异常表达,提示可能与前列腺癌的发生、发展有关。[Objective] To investigate the expressions of special AT-rich sequence-binding protein 1 （SATB1） and P504s in human prostatic carcinoma tissue and their clinical significance. [Methods] Expressions of SATB1 and P504s protein were assessed by immunohistochemistry in 60 cases of prostatic carcinoma （ group PC） and 30 cases of benign prostatic hyperplasia （group BPH）. [Results] The expression of SATB 1 in the group PC （78.3%） was significant higher than that in the group BPH （0.0%）, the difference was significant （P〈 0.05）. The expression of P504s was also much higher in the group PC （95.0%） than that in the group BPH （0.0%） with a significant difference （P 〈 0.05）. And the expression of SATB 1 was increased with the increase of Gleason score, but the expression of P504s did not increase as the grade of Gleason score increased （P〉0.05）. [Conclusions] Combined with meta-analysis, the high expressions of SATB1 and P504s in the PC tissue will contribute to improve pathological diagnosis and differential diagnosis for prostatic carcinoma. Over-expression of SATB1 might be involved in the pathogenesis and development of prostatic carcinoma.

关 键 词：前列腺癌 特异AT序列结合蛋白1 P504S 免疫组织化学法 

分 类 号：K737.25[历史地理—历史学]