试论“风药”止血作用及其机理  

Hemostatic effect and mechanism of wind-dispelling Chinese medicinal herbs

作　　者：胡红林[1] 杨桢[1] 鲁赛[1] 高琳[1] 

机构地区：[1]北京中医药大学基础医学院,北京100029

出　　处：《北京中医药大学学报》2015年第7期444-446,共3页Journal of Beijing University of Traditional Chinese Medicine

基　　金：北京中医药大学自主课题项目(No.2013JYBZZJS116)

摘　　要："风药"具有止血作用,在出血证中被广泛使用。古人在临床用药经验归纳总结的基础上,逐渐形成了"风伤荣"以致出血的中医理论,即风性主动,血随风动,血不得所藏,流不归经而致出血,并提出以"风药"止血的治疗方法。现代文献表明,跟出血证密切相关的诱导型一氧化氮合酶(i NOS)具有重要的抗凝血作用,主要通过诱导产生大量的一氧化氮(NO)和激活促进环氧合酶-2(COX-2)的表达实现。而现代药理研究显示,风药能够从多个环节抑制i NOS的基因表达,进而抑制大量NO的产生和COX-2的表达,促进血小板黏附聚集及血管收缩,达到止血的效果,风药的这种止血作用机理很可能与其抗炎作用使炎症因子减少有关。Wind-dispelling Chinese medicinal herbs were widely used in syndrom of bleeding due to the effect of hemostasis. Based on the experiences of clinical practice, the ancient TCM physicians summarized that bleeding was caused by＂wind pathogen damaged blood＂, that is to say, wind pathogen, tending to move and change, blowed the blood to flow outside the channels. While modern medical literature showed that inducible nitric oxide synthase （iNOS） was the key factor closely related to syndrom of bleeding, the anticoagulant effect of iNOS worked mostly through producing a large amount of nitric oxide（NO） and promoting expression of cyclooxygenase- 2（COX-2）. Wind-dispelling medicine could down-regulate gene expression of iNOS at dif- ferent steps to inhibite the production of NO and expression of COX-2, so as to promote platelet adhesion and aggregation and vasoconstriction. The hemostatic mechanism of wind-dispelling medicine is potentially related to the anti-inflammatory effects reducing inflammatory cytokines.

关 键 词：风药 止血 一氧化氮合酶 环氧合酶-2 

分 类 号：R287[医药卫生—中药学]