4-氨基-1,1,1-三氟-3-丁烯-2-酮的合成  

Synthesis of 4-amino-1,1,1-trifluoro-3-buten-2-one

作　　者：顾嘉超 李玉峰[1] 黄佳维 钮长盛 叶志祥[1] 马鸿飞[1] 

机构地区：[1]南京工业大学,江苏南京211816

出　　处：《广东化工》2015年第15期22-22,15,共2页Guangdong Chemical Industry

摘　　要：三氟乙酸脱水生成三氟乙酸酐,与乙烯基乙醚反应,在链上引入三氟甲基基团,再经过氨解反应,生成4-氨基-1,1,1-三氟-3-丁烯-2-酮。以乙烯基乙醚计,产品总收率达80%以上,产品结构经核磁共振分析验证。探讨了原料配比、反应温度、时间等因素对反应收率的影响。According to the reference and mechanism analysis, several possible synthesis methods were designed in this dissertation. Starting from ethyl vinyl ether and trifluoroacetic acid, pulling the trifluoromethyl in the chain, then though amination, synthesizing 4-amino-1,1,1-trifluoro-3-buten-2-one, in a total yield of 80 %, which is a key intermediate of 4-trifluoromethylnicotinic acid. The structure was confirmed by NMR analysis. The influence of the ratio of reactants, temperature and time factor on the yield was investigated.

关 键 词：三氟乙酸 乙烯基乙醚 4-氨基-1 1 1-三氟-3-丁烯-2-酮 合成 

分 类 号：TQ[化学工程]