2-苯氧基-5-乙酰吡啶的合成研究  

Study on the Synthesis of 2-Phenoxy-5-acetyl Pyridine

作　　者：于康平 陈辉 李泽方 罗志会 

机构地区：[1]江苏耕耘化学有限公司,江苏连云港222523 [2]金坛市环境监测站,江苏金坛213200

出　　处：《广东化工》2015年第15期70-70,74,共2页Guangdong Chemical Industry

基　　金：国家"十二五"科技支撑计划(2012BAK25B03-4)

摘　　要：文章研究了以6-氯烟酸为主要原料,通过酰化、酯化、水解3步反应得到2-氯-5-乙酰基吡啶,再与苯酚缩合得到2-苯氧基-5-乙酰基吡啶的合成工艺。中间体2-氯-5-乙酰基吡啶和终产物2-苯氧基-5-乙酰基吡啶均经1H NMR和MS确认。2-chloro-5-acetyl pyridine was synthesized through acylation, esterification, and hydrolysis reactions using 6-chloronicotinic acid as the starting material. The target compound of 2-phenoxy- 5-acetyl pyridine was synthesized through condensation reaction of 2-phenoxy-5-acetyl pyridine with phenol. Both the intermediate of 2-chloro-5-acetyl pyridine and the target compound of 2-phenoxy-5-acetyl pyridine were confirmed by 1H NMR and MS.

关 键 词：合成 6-氯烟酸 2-氯-5-乙酰基吡啶 2-苯氧基-5-乙酰基吡啶 

分 类 号：TQ[化学工程]