手性联萘双噁唑啉配体合成方法的改进  

Improvement for the Synthesis of(4S, 4'S)-.2,2'-Bis(oxazolyl)-l, l'-binaphthyls

作　　者：徐桂英[1] 

机构地区：[1]广州金域医学检验中心有限公司,广东广州510330

出　　处：《广东化工》2015年第16期76-77,共2页Guangdong Chemical Industry

摘　　要：以消旋的1,1'-联-2-萘酚做为起始原料,经过手性拆分、萘酚的三氟甲基磺酸酯化、钯催化偶联和三氟甲基磺酸锌促进的缩合环化四步反应合成了手性联萘双噁唑啉配体,总产率达31.4%。反应中间体和目标产物经核磁1H NMR,IR和LCMS等手段进行了表征,结果与化合物结构一致。（4S, 4＇S）-.2,2＇-Bis（oxazolyl）-l,l＇-binaphthyls was synthesized from the following steps： racemic 1,1＇-Bi-2-naphtholas resolution、phenolic hydroxyl protection、palladium catalyzed coupling reaction and Zn（OTf）2 promoted condensation and cyclization reaction. The total yield up to 31.4 %.The intermediate and desired product were both characterized by 1H NMR, IR and LCMS which were consistent with proposed structures.

关 键 词：消旋联萘酚 钯催化偶联 缩合环化 合成改进 

分 类 号：O625.5[理学—有机化学]