微RNA在非酒精性脂肪性肝病中的作用  

The Role of MicroRNA in Nonalcoholic Fatty Liver Diseases

作　　者：于俊杰[1] 詹晓蓉[1] 

机构地区：[1]哈尔滨医科大学附属第一医院内分泌科,哈尔滨150001

出　　处：《医学综述》2015年第16期2901-2903,共3页Medical Recapitulate

摘　　要：微RNA(miRNA)是一类长约22个核苷酸的内源性非蛋白质编码的小分子RNA,它通过对目标mRNA的剪切和翻译抑制,发挥对基因表达的转录后调控作用。miRNA具有多靶点的特性,至少参与约1/3人类蛋白质的表达调控,并且参与调控细胞分化、凋亡,肿瘤形成、免疫反应等多种生物学行为。近些年研究表明,miRNA对于调控非酒精性脂肪性肝病的基因表达、调节脂质形成和储存至关重要。MicroRNA（ miRNA） is a class of 22 nucleotides endogenous non-protein-coding small molecule RNA,which regulates gene expression after transcription through splicing and translation of the target mRNA inhibition. miRNA has multiple targets,and is involved in the expression regulation of at least about1 /3 human protein,and participates in biological behaviors including the regulation of cell differentiation,apoptosis,tumor formation,and immune response. In recent years,research shows that miRNA is essential to the regulation of gene expression of nonalcoholic fatty liver disease,lipid formation and storage.

关 键 词：微RNA 非酒精性脂肪性肝炎 非酒精性脂肪性肝病 代谢综合征 

分 类 号：R58[医药卫生—内分泌]