D-二聚体的临床应用价值  

The Clinical Value of D-Dimer

作　　者：尤立蕊 唐梅[1] 

机构地区：[1]首都医科大学附属北京友谊医院医疗保健中心内科,北京100050

出　　处：《医学综述》2015年第16期2965-2967,共3页Medical Recapitulate

基　　金：国家科技支撑计划(2014BAI11B00)

摘　　要：D-二聚体是交联纤维蛋白降解后的一种特异性产物。其水平增高提示体内凝血酶的生成及继发性纤溶系统的激活,是血栓前状态的一个敏感指标,与临床中的血栓性疾病密切相关。特别是针对肺栓塞,作为一个早期的筛查指标,具有高度的敏感性,减少了肺栓塞的误诊及漏诊。近年来,临床中发现在主动脉夹层、恶性肿瘤、急性脑梗死、心房颤动等疾病中D-二聚体水平亦有升高。对于此类疾病的早期诊断、评估治疗效果及其预后具有重要意义。D-Dimer is a specific degradation product of cross-linked fibrin and its increased level in plasma is a biomarker indicating activation of coagulation and fibrinolysis,therefore it is a sensitive index of venous thromboembolism,especially in the pulmonary embolism（ PE） for its early screening with high sensitivity,which reduces the misdiagnosis,and missed diagnosis of PE. Recently,it＇ s discovered that D-dimer level also increases in acute aortic dissection,cancer,acute stroke,atrial fibrillation,therefore it＇s also of great significance for the early diagnosis,treatment effect assessment and prognosis of these diseases.

关 键 词：肺栓塞 心血管疾病 恶性肿瘤 脑梗死 D-二聚体 临床价值 

分 类 号：R446[医药卫生—诊断学]