调节性T细胞检测在浆细胞性乳腺炎患者筛查中的临床价值  

Clinical Value of Regulatory T Cell Detection in Diagnosis of Patients with Plasma Cell Mastitis

作　　者：高双英[1] 吴静 

机构地区：[1]武汉科技大学校医院检验科,武汉430081 [2]华润武钢总医院检验科,武汉430081

出　　处：《医学综述》2015年第16期3060-3062,共3页Medical Recapitulate

摘　　要：目的探讨调节性T细胞检测在浆细胞性乳腺炎(PCM)诊断中的临床价值。方法将2008年5月至2013年5月华润武钢总医院收治的62例PCM患者按照病程分为急性期(18例)、亚急性期(31例)和慢性期(13例);另选择30例乳腺癌患者和30例健康女性作为乳腺癌组和健康对照组;比较各组外周血CD4+CD25+CD127-调节性T细胞水平变化。结果健康对照组、乳腺癌组、PCM组外周血CD4+CD25+CD127-T细胞、CD4+CD25+Fox P3+T细胞百分率、转化生长因子β(TGF-β)分别为(4.0±1.8)%、(4.4±1.4)%、(87±16)mg/L;(3.0±0.5)%、(2.4±1.1)%、(53±19)mg/L;(5.8±2.2)%、(5.5±1.0)%、(385±37)mg/L。PCM组显著低于健康对照组(P<0.05);乳腺癌组患者各指标显著高于对照组(P<0.05)。急性期PCM组CD4+CD25+CD127-T细胞、CD4+CD25+Fox P3+T细胞、TGF-β为(2.8±1.2)%、(1.6±0.7)%、(35±11)mg/L,亚急性期分别为(3.1±1.2)%、(2.4±1.0)%、(56±14)mg/L,慢性期为(3.5±1.2)%、(3.3±1.3)%、(70±22)mg/L,急性期显著低于亚急性期和慢性期,亚急性期显著低于慢性期(P<0.05)。相关性分析显示,CD4+CD25+CD127-T细胞与CD4+CD25+Fox P3+T细胞、TGF-β呈正相关(r=0.589,0.724,P<0.05),与C反应蛋白、红细胞沉降率、Ig A、Ig G、Ig M、C3、C4、血小板计数、血红蛋白无明显相关性(P>0.05)。结论 PCM患者外周血CD4+CD25+CD127-T细胞显著降低,可以作为筛查PCM的指标之一。Objective To explore the clinical value of regulatory T cell detection diagnosis in patients with plasma cell mastitis（ PCM）. Methods A total of 62 cases of PCM treated in Huarun Group Wuhan Steel General Hospital during May 2008 and May 2013 according to the disease course were divided into18 cases of acute phase,31 cases of subacute phase and 13 cases of chronic phase; another 30 cases of breast cancer patients and 30 healthy women were selected as breast cancer group and healthy control group; the peripheral blood levels of CD4＋CD25＋CD127-regulatory T cells of each group were compared. Results The peripheral blood level of CD4＋CD25＋CD127T cells,the percentage of CD4＋CD25＋Fox P3＋T cells,transforming growth factor β（ TGF-β） in the healthy control group,breast cancer group,PCM group were（ 4. 0 ± 1. 8） %,（ 4. 4 ± 1. 4） %,（ 87 ± 16） mg/L;（ 3. 0 ＋ 0. 5） %,（ 2. 4 ± 1. 1） %,（ 53 ± 19） mg/L;（ 5. 8 ± 2. 2） %,（ 5. 5 ± 1. 0） %,（ 385 ± 37） mg/L. The PCM group＇s indexes were significantly lower than the healthy control group（ P 0. 05）; and the breast cancer group＇s indexes were significantly higher than the healthy control group（ P 0. 05）. Peripheral blood CD4＋CD25＋CD127-T cells,the percentage of CD4＋CD25＋Fox P3＋T cells,TGF-β in the acute phase of PCM group were（ 2. 8 ± 1. 2） %,（ 1. 6 ± 0. 7） %,（ 35 ± 11） mg/L,were significantly lower than that of the subacute phase（ 3. 1 ± 1. 2） %,（ 2. 4 ± 1. 0） %,（ 56 ± 14） mg/L and chronic phase（ 3. 5 ± 1. 2） %,（ 3. 3 ± 1. 3） %,（ 70 ± 22） mg/L,the acute phase were significantly lower than those of the subacute phase and chronic phase,the subacute phase were significantly lower than the chronic phase（ P 0. 05）. Correlation analysis showed that the relationship between CD4＋CD25＋CD127-T cells and CD4＋CD25＋Fox P3＋T cells,TGF-β were positively correlated（ r = 0. 589,0. 724,P 0. 05）,but had no obvious correction with C-reactive protein,ery

关 键 词：浆细胞性乳腺炎 调节性T细胞 FOX P3 相关性 

分 类 号：R655.8[医药卫生—外科学]