血清新喋呤在肾炎患者病程中的检测及意义  

Measurement of serum neopterin in patients with nephritis and its significance

作　　者：田连芳[1] 王欣荣[1] 左江华[1] 孙建[1] 任宏涛[1] 李会平[1] 李书君[1] 孙春秀[1] 

机构地区：[1]邢台市人民医院检验二科,河北邢台054001

出　　处：《国际检验医学杂志》2015年第16期2382-2383,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨血清新喋呤(Npt)在肾炎患者病程中的表达及新喋呤与急、慢性肾炎的预后关系。方法对40例急性肾炎患者(A1组)和30例慢性肾炎患者(A2组)按病期采血,分别用酶联免疫吸附试验(ELISA)检测Npt的水平,用日立全自动生化分析仪检测血清肌酐(Cr)和尿素氮(BUN)的水平。另取50例健康献血者(B组)作为对照组(B组)。结果 A1、A2组血清Npt浓度明显高于B组(P<0.05),A1、A2组之间Npt水平也有差异(P<0.05),且A1组、A2组与B组比较,Cr和BUN明显增高,差异有统计学意义(P<0.05)。结论血清Npt是肾炎患者病情进展及早期诊断的敏感指标,对疾病的诊断及疗效监测有一定的临床价值。Objective To evaluate the expression of serum neopterin in nephritic patients and its relationship with the prognosis of acute and chronic nephritis.Methods The levels of serum neopterin were determined in 40 patients with acute nephritis （A1 group）and 30 patients with chronic nephritis （A2 group）by enzyme-linked immunosorbent assay.The contents of serum creatinine and blood urea nitrogen were determined by Hitachi fully automatic biochemical analyzer.50 healthy blood donors were in the control group.Results The levels of serum neopterin in acute nephritis and chronic nephritis were significantly higher than that in the normal group（P〈0.05）.The levels of serum neopterin in acute nephritis were significantly higher than that in chronic nephritis（P＆lt;0.05）.The levels of serum creatinine and blood urea nitrogen in two nephritis group were significantly higher than that in the normal group（P〈0.05）.Conclusion The measurement of the serum neopterin may be a useful sensitive index for early diagnosis. This may be helpful for diagnosis and evaluation of therapy effect.

关 键 词：新喋呤 肾炎 肌酐 尿素氮 

分 类 号：R692.3[医药卫生—泌尿科学] R446.11[医药卫生—外科学]