脂康颗粒配合非诺贝特治疗高脂血症疗效观察  

Curative effect of Zhikang Granules combining fenofibrate in patients with hyperlipidemia

作　　者：何海洲[1] 李伯英 

机构地区：[1]都江堰市人民医院中西医结合科,都江堰611830 [2]都江堰市中医院内科

出　　处：《中国循证心血管医学杂志》2015年第4期530-532,共3页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的探讨脂康颗粒联合非诺贝特治疗高脂血症的临床疗效及安全性。方法将76例高脂血症患者随机分为试验组和对照组。试验组予以脂康颗粒联合非诺贝特治疗,对照组予以非诺贝特及安慰剂治疗。非诺贝特200 mg 1/日,脂康颗粒及安慰剂用量为8 g,2/日,两组均连续用药8周。观察两组治疗前后血脂变化、总有效率及不良反应等。结果治疗后患者总胆固醇、三酰甘油及低密度脂蛋白胆固醇下降幅度均高于对照组(P<0.05),高密度脂蛋白胆固醇上升幅度也高于对照组(P<0.05)。试验组降脂总有效率为92.3%,明显高于对照组(75.7%),差异有统计学意义(P<0.05)。治疗后试验组丙氨酸氨基转移酶及天冬氨酸氨基转移酶水平均较治疗前明显降低(P<0.05),对照组无明显变化(P>0.05)。结论脂康颗粒联合非诺贝特治疗高脂血症,不仅有协同降脂作用,还具有保肝降酶的疗效。Objective To investigate the clinical efficacy and safety of Zhikang Granules combining fenofibrate in patients with hyperlipidemia. Methods The patients （n=76） were randomly divided into test group and control group. The test group was given Zhikang Granules （8 g twice a day） combining fenofibrate （200 mg once a day） and control group was given fenofibrate （200 mg once a day） and placebo （8 g twice a day） for 8 w. The changes of blood fat, total effective rate and adverse reactions were observed in 2 groups. Results The decrease degree of total cholesterol （TC）, triglyceride （TG） and low-density lipoprotein-cholesterol （LDL-C） was higher （P〈0.05） and increase degree of high-density lipoprotein-cholesterol （HDL-C） was higher （P〈0.05） in test group than those in control group. The total effective rate was 92.3%in test group and 75.7%in control group （P〈0.05）. After treatment, ALT and AST decreased significantly in test group （P〈0.05） and had no significant changes in control group （P〉0.05）. Conclusion Zhikang Granules combining fenofibrate has not only cooperative effect of reducing blood fat, but also curative effect of protecting liver and lowering transaminase in the treatment of hypertension.

关 键 词：脂康颗粒 非诺贝特 高脂血症 

分 类 号：R589.2[医药卫生—内分泌]