自拟益气解毒化瘀汤治疗难治性丙型肝炎临床研究  

Clinical Study on Self-made Yiqi Jiedu Huayu Decoction for Treatment of Refractory Hepatitis C

作　　者：侯小兰 

机构地区：[1]郴州市第二人民医院肝病中心,湖南郴州423000

出　　处：《中国中医药信息杂志》2015年第9期33-36,共4页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的观察自拟益气解毒化瘀汤治疗难治性丙型肝炎的临床疗效。方法将60例患者用随机数字表法分为中药组和西药组,每组30例。中药组予自拟益气解毒化瘀汤治疗,西药组予聚乙二醇干扰素联合利巴韦林治疗。2组疗程均为12个月。观察2组治疗前后中医证候积分、丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST)水平、丙型肝炎病毒(HCV)RNA载量,对临床疗效进行对比分析。结果中药组总有效率为80.00%(24/30),与西药组比较,差异有统计学意义(P<0.05);中药组中医证候积分、ALT水平及HCV RNA载量改善优于西药组,差异有统计学意义(P<0.05)。结论益气解毒化瘀汤能明显改善患者的临床症状和体征,且有一定的抗病毒作用,有助于提高临床疗效。Objective To observe the clinical efficacy of self-madeYiqi Jiedu Huayu Decoction for treatment of refractory hepatitis C.Methods Sixty cases were randomly divided into Chinese herbal medicine （CHM） group and Western medicine （WM） group, 30 cases in each group. The CHM group was treated by self-madeYiqi Jiedu HuayuDecoction, while the WM group was treated by peginterferon and ribavirin. The course for the two groups lasted for 12 months. TCM syndrome scores, level of ALT and AST, HCV RNA load were observed, and clinical efficacy were analyzed comparatively.Results The total effect rate of CHM group was 80.00% （24/30）, with statistical difference compared with the WM group （P〈0.05）. TCM syndrome scores, level of ALT and HCV RNA load of CHM group were improved better than those of the WM group, with statistical differences （P〈0.05）.Conclusion Self-madeYiqi Jiedu Huayu Decoction can obviously improve clinical symptoms and signs, and has positive antiviral effect, which can help to improve the clinical efficacy.

关 键 词：难治性丙型肝炎 益气解毒化瘀汤 临床疗效 

分 类 号：R259.751[医药卫生—中西医结合]