复方α-酮酸片对维持性血液透析患者营养状态、钙磷代谢及炎性因子的影响  

Effect of compoundα-keto acid tablets on nutritional status,calcium-phosphorus metabolism and inflammatory factors in patients with maintenance hemodialysis

作　　者：奚敏慧[1,2] 毛佩菊 张旦欢 陈凌云 

机构地区：[1]上海市同仁医院肾脏内科,上海200336 [2]同济大学医学院,上海200092

出　　处：《海南医学院学报》2015年第8期1057-1059,共3页Journal of Hainan Medical University

基　　金：中国临床医学诊疗技术创新发展专项基金(320.6750.14201)~~

摘　　要：目的:探讨复方α-酮酸片对维持性血液透析患者营养状态、钙磷代谢及炎性因子的影响。方法:选取维持性血液透析患者84例,按照就诊顺序随机分为观察组和对照组两组,各为42例。对照组单纯给予维持性血液透析治疗,观察组在对照组的基础上加用复方α-酮酸片,比较两组治疗前后血清总蛋白(TP)、血清白蛋白(ALB)、血红蛋白(HB)、转铁蛋白(TRF)、血钙(Ca)、血磷(P)、钙磷乘积(Ca×P)、血清全段甲状旁腺素(iPTH)收、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)及超敏C反应蛋白(hsCRP)的变化情况。结果:观察组治疗后TP、ALB、HB、TRF均明显高于对照组,差异具有统计学意义(P<0.05),而血P、血Ca×P、血清iPTH明显低于对照组,差异具有统计学意义(P<0.05),血清IL-6、TNF-α及hs-CRP水平明显低于对照组,差异具有统计学意义(P<0.05)。结论:复方α-酮酸片能够有效改善血液透析患者的营养状态,维持其钙磷代谢平衡,并能降低炎性反应,值得临床推广和应用。Objective： To investigate the effects of compound a-keto acid tablets on nutritional status, calcium-phos- phorus metabolism and inflammatory factors in patients with maintenance hemodialysis. Methods.. 84 patients with mainte- nance hemodialysis were enrolled and randomly divided into observation group and control group with 42 cases in each group. The control group were treated with maintenance hemodialysis, the observation group were treated with compound a-keto acid tablets based on treatments of the control group. The serum total protein （TP）, serum albumin（ALB）, hemoglobin （HB）, transferrin （TRF）, calcium （Ca）, phosphorus （P） ,calcium phosphorus product （Ca）〈 P） , serum intact parathyroid hormone （iPTH） ,interleukin 6 （IL-6）, tumor necrosis factor alpha （TNF- alpha） and high sensitive C reactive protein （hs-CRP） of two groups were tested before and after treatment. Results.. After treatment, the TP, ALB, HB, TRF of observation group were significantly higher than those in the control group （P〈0.05）, and blood P, blood CaX P, serum iPTH were significantly lower than the control group （P〈0.05）, serum IL-6, TNF- alpha and hs-CRP levels were significantly lower than those of the control group （P〈0.05）. Conclusion.. Compound a-keto acid tablets can effectively improve the nutritional status of hemodial- ysis patients, maintain the metabolism of calcium and phosphorus balance, and can reduce the inflammatory reaction, ant it is worth the clinical promotion and application .

关 键 词：复方Α-酮酸 维持性血液透析 营养状态 钙磷代谢 炎性因子 

分 类 号：R459.5[医药卫生—治疗学]