脓毒症患者血浆中抗AT-Ⅲ水平测定的临床意义  

Clinical significance of plasma level of AT-Ⅲ determination in sepsis patients

作　　者：陈伟[1] 胡志华[1] 陈勉[1] 

机构地区：[1]海南医学院附属医院重症医学科,海南海口570102

出　　处：《海南医学院学报》2015年第8期1060-1061,1065,共3页Journal of Hainan Medical University

摘　　要：目的:通过测定脓毒症患者血浆中抗凝血酶Ⅲ(anticoagulant enzyme,AT-Ⅲ)活性变化,探讨AT-Ⅲ活性变化对预测脓毒症发生与预后的临床意义。方法:对非脓毒症患者30例,脓毒症患者76例,其中严重脓毒症25例,应用凝血酶凝胶空斑方法测定血浆中AT-Ⅲ活性,同时进行血小板计数和APACHEⅡ(急性生理和慢性健康)评分。结果:脓毒症组、严重脓毒症组分别与对照组对比,AT-Ⅲ活性明显降低(P<0.01),严重脓毒症组AT-Ⅲ活性低于脓毒症组(P=0.05)。结论:脓毒症早期AT-Ⅲ活性开始降低,随病情加重,其测定值进一步降低,提示AT-Ⅲ活性测定对预测脓毒症发生的及其预后判断有一定临床意义。Objective： Through measuring changes of anticoagulant enzyme （AT-Ⅲ） activity in plasma in sepsis pa- tients, this paper discusses the clinical significance of AT- Ⅲ activity changes in predicting sepsis occurrence and prognosis. Methods： 30 cases of the non--sepsis patients, with sepsis for 76 cases, including 25 cases of severe sepsis patients, the meth- od of thrombin gelatum lacuna was used to determine the activity of AT-- IlI in plasma, platelet count and APACHE 11 score simultaneously. Results： The sepsis group and the severe sepsis group are contrasted with the non--sepsis group respectively, the activity of AT-- m reduced significantly （ P〈 0.01）, the severe sepsis group is lower than the sepsis group （ P = 0.05）. Conclusion： AT--Ⅲ activity reduced early in sepsis patients, with patient＇s condition aggravating, its value was further re- duced, thus hinting that the measurement of AT-- Ⅲ activity has certain clinical significance in predicting sepsis occurrence and prognosis.

关 键 词：脓毒症 抗凝血酶(AT-Ⅲ) 

分 类 号：R613[医药卫生—外科学]