低温等离子刀联合匹多莫德治疗复发性小儿喉乳头状瘤的疗效分析  

Evaluate the Efficacy of Low-temperature Plasma Cutter Combined with Pidotimod on Recurrent Juvenile Laryngeal Papilloma

作　　者：岑瑞祥[1] 万浪[1] 彭聪[1] 陈艳丹[1] 崔珑[2] 

机构地区：[1]湖北省黄石市中心医院(湖北理工学院附属医院)耳鼻咽喉科,湖北黄石435000 [2]武汉市儿童医院,湖北武汉430060

出　　处：《武汉大学学报（医学版）》2015年第5期779-782,共4页Medical Journal of Wuhan University

摘　　要：目的:研究低温等离子刀联合匹多莫德对小儿喉乳头状瘤的治疗效果。方法:对黄石市中心医院及武汉市儿童医院2009-2014年诊疗的小儿喉乳头状瘤43例完整随访病历资料进行分析。根据治疗方法分为CO2激光联合匹多莫德组(A组)及低温等离子刀联合匹多莫德组(B组)。记录不同方法治疗后患儿肿瘤复发情况,统计复发率和复发时间,并运用解剖划分法,以此作为不同方法治疗的疗效指标。结果:两组复发率统计学无差异(61.90%vs 59.09%)(P>0.05),但B组复发时间[(8.13±1.17)月]要长于A组[(6.21±1.08月])(P<0.05);两组术前平均解剖亚区为(3.85±1.45)和(3.64±1.57),两组之间无统计学意义(P>0.05),术后3月和6月A组平均(1.82±0.98)和(2.52±1.18)个解剖亚区,B组平均(1.28±0.69)和(1.88±0.79)个解剖亚区,B组均要少于A组,差异有统计学意义(P<0.05)。结论:低温等离子刀联合匹多莫德治疗小儿乳头状瘤,能够有效延长肿物复发时间,使乳头状瘤复发范围较小,值得在临床上推广应用。Objective： To observe the effect of the treatment for pediatric laryngeal papilloma by low- temperature plasma cutter combined with pidotimod. Methods： 43 complete follow-up medical re- cords of pediatric laryngeal papilloma were retrospectively analyzed from 2005 to 2014 in Huangshi Central Hospital and the Children＇s Hospital of Wuhan, according to the treatment methods, they were divided into CO2 laser microsurgery combined with pidotimodr group （Group A） and low-temperature plasma cutter combined with pidotimod group （Group B）, the recurrences of different groups were recorded, analysis recurernee rate and time with the tumor recurrence, the number of anatomical sites involved by papilloma were counted before and after the treatment, which were regarded as efficacy indicators of different treatment methods. Results： There was no significant difference in the recurrence rate between the two groups（ 61. 90%vs59.09%）（P〉0.05） ,and the recurrence time（[8.13±1.17] month ） of group B was longer than that of group A（[-6. 21±1. 08-] months）（P〈0.05）. The number of anatomical sites involved by papilloma before operation were the average of 3.85±1.45 in group A and 3.64±1.57 in group B, the difference was not statistically significant（P〉0.05）. At 3 months after the treatment, the number of anatomical sites turned into group A and group B with the average value of 1.82 ±0.98 and 1.28 ±0.69 ,at 6 months1 to 5 in group A and 1 to 4 in group B w ith the average value of 2.52±1.18 and 1.88 ±0.79,the number of anatomical sites of group B was less than that of group A, the difference was statistically significant （P〈0.05）. Conclusion： The Low-temperature plasma cutter combined with pidotimod to treat pediatric laryngeal papilloma can effectively extend tumor recurrence time and decrease the number of sites involved by papilloma ,which is worth promotion in clinical application.

关 键 词：复发性小儿喉乳头状瘤 等离子刀 激光 匹多莫得 复发 

分 类 号：R767.1[医药卫生—耳鼻咽喉科]