自拟灌肠方治疗慢性肾功能不全(失代偿期)患者的临床疗效观察  

Observation on the curative effect of prescription of enema in patients with chronic renal failure

作　　者：王岩[1] 张博 孙安凤[1] 

机构地区：[1]长春市人民医院内三科,吉林长春130000 [2]长春市张博中医内科诊所,吉林长春130000

出　　处：《中国现代医生》2015年第17期130-132,共3页China Modern Doctor

摘　　要：目的探讨自拟灌肠方对慢性肾功能不全（失代偿期）患者肾功能及凝血功能的影响。方法将CRF患者120例随机分为两组：对照组使用常规西药对症治疗,治疗组在常规治疗基础上,每日晚间加用自拟灌肠方（大黄20~30 g后下、牡蛎30 g先煎、黄芪40~60 g、丹参30 g、蒲公英30 g）灌肠治疗;分别于治疗1个月后观察血肌酐（Scr）、血尿素氮（BUN）、血二氧化碳结合力（CO2CP）、凝血酶原时间（PT）、部分活化凝血活酶时间（APTT）、纤维组织蛋白原（FDP）等的变化。结果治疗1个月后,治疗组血肌酐、血尿素氮较对照组显著下降（P〈0.05）,同时对高凝状态的改善明显优于对照组（P〈0.05）,总有效率明显高于对照组（P〈0.05）。结论自拟灌肠方可能通过更好地改善凝血机制,增加残存肾单位的血流量,对慢性肾功能不全（失代偿期）患者治疗取得更好的效果。Objective To observe the effect on renal function and hypercoagulative state of prcscription of enema with chronic renal failure. Methods All 120 patients with chronic renal failure were randomly divided into treatment group and control group. On the basis of conventional treatment in both groups, the treatment group was treated by prcscrip- tion of enema. The changes of the serum PT, APTT, FDP, BUN, SCR and CO2CP were observed before treatment and after 1-month treatment. Results After 1-month treatment, the level of BUN and SCR was decreased compared with the control group （P〈0.05）. The levels of PT and APTT were significantly improved in the treatment group compared with the control group （P〈0.05）. The FDP level was decreased compared with the control group （P〈0.05）. Conclusion Our prcscription of enema has better therapeutic effect on primary nephrotic syndrome by improving hypercoagulative state and renal blood flow.

关 键 词：慢性肾功能不全(CRF) 自拟灌肠方 高凝状态 

分 类 号：R277.51[医药卫生—中医学]