我院2008～2014年胺碘酮不良反应的临床表现分析  

Clinical manifestations analysis of amiodarone-induced adverse reactions in our hospital from 2008 to 2014

作　　者：彭庚[1,2] 谢文燕[1,2] 

机构地区：[1]漯河医学高等专科学校第一附属医院 [2]漯河市中心医院心内科,河南漯河462000

出　　处：《中国现代医生》2015年第15期70-72,75,共4页China Modern Doctor

摘　　要：目的分析我院胺碘酮所致不良反应（ADR）的发生特点及相关因素,为临床安全、合理用药提供参考。方法收集我院2008年1月~2014年6月住院及门诊患者中胺碘酮ADR报告,对胺碘酮ADR的临床表现、处理及转归等信息进行统计分析。结果本院上报的120例胺碘酮ADR报告中,男性、高龄、原患心血管疾病、注射剂的ADR比例偏高,严重ADR发生率低（16.67%）;主要临床表现为肝损害（36.67%）、静脉炎（30.83%）、过敏样反应及过敏性休克（11.67%）、皮疹（7.50%）、低血压及心律失常（5.83%）、甲状腺功能异常（4.17%）、肺损害（3.33%）;经减量、停药、积极临床治疗等处理后治愈35例（29.17%）,好转76例（63.33%）,有后遗症8例（6.67%）,死亡1例（0.83%）。结论胺碘酮是比较安全的抗心律失常药,但其ADR表现多样,在临床工作中应严格遵守其适应证,严密监测ADR情况,减少严重不良事件发生。Objective To analyze the occurrence characteristics and related factors of amiodarone-induced adverse re- actions （ADR） in our hospital so that we can provide reference for clinical safety, rational drug use. Methods Amio- darone-induced ADR reports of inpatient and outpatient in our hospital from January 2008 to June 2014 were collected, and amiodarone-induced ADR clinical manifestations, treatment and outcome and other information were statistically analyzed. Results In amiodarone-induced ADR reports of the reported 120 cases in our hospital, ADR proportions of men and people with advanced age, original cardiovascular diseases or injections, were slightly high ,and there was a low incidence of severe ADR （16.67%）. The main clinical manifestations were liver damage （36.67%）, phlebitis （30.83%）, allergic-like reactions and anaphylactic shock（11.67%）, rash（7.50%）, hypotension and arrhythmias （5.83%）, thyroid dysfunction （4.17%） and lung damage （3.33%）. After drug reduction, drug withdrawal, active clinical treat ment and other treatments, 35 cases （29.17%） cured and 76 cases （63.33%） improved, with 8 cases （6.67%） of sequelae and 1 case of death （0.83%）. Conclusion Amiodarone is a kind of relatively safe antiarrhythmic drugs, but its ADR manifestations are various. We should restrict indications and closely monitor ADR in order to reduce the oc- currence of serious adverse events in clinical work.

关 键 词：胺碘酮 药品不良反应 临床表现 

分 类 号：R541.7[医药卫生—心血管疾病] R972.2[医药卫生—内科学]