门冬胰岛素与地特胰岛素联合治疗2型糖尿病的疗效评价  

Effect of insulin aspart and insulin detemir in treatment of type 2 diabetes

作　　者：杨旭[1] 秦蕾[2] 赵秀云[1] 

机构地区：[1]吉林油田总医院内分泌科,吉林松原138000 [2]吉林油田总医院检验科,吉林松原138000

出　　处：《中国现代医生》2015年第21期27-29,共3页China Modern Doctor

摘　　要：目的探讨门冬胰岛素与地特胰岛素联合治疗2型糖尿病的疗效。方法收集2014年1月~2015年4月期间我院收治的2型糖尿病患者146例,随机分为观察组和对照组各73例,观察组用门冬胰岛素联合地特胰岛素治疗,对照组用门冬胰岛素治疗。治疗4周后比较两组FPG、2h PG、Hb A1c水平、血糖达标时间、低血糖发生率及胰岛素用量。结果治疗后观察组和对照组FPG、2h PG、Hb A1c水平均明显低于治疗前,差异有统计学意义（P〈0.05）;观察组治疗后FPG、2h PG、Hb A1c水平、血糖达标时间、低血糖发生率及胰岛素用量与对照组比较,差异无统计学意义（P〉0.05）。结论 2型糖尿病患者用门冬胰岛素联合地特胰岛素治疗的临床效果与单独应用门冬胰岛素相近,均可有效降低患者的血糖水平,均有较高的安全性。Objective To investigate the effect of insulin aspart and insulin detemir in treatment of type 2 diabetes. Methods A total of 146 cases with type 2 diabetes were selected from January 2014 to April 2015 in our hospital and were randomly divided into the observation group and the control group, each had 73 cases respectively. The observa- tion group was treated with insulin detemir combined with insulin aspart, while the control group was treated with in- sulin aspart. After four weeks of treatment, FPG, 2hPG, HbAlc levels, blood glucose time, the incidence of hypo- glycemia and insulin dosage of two groups were compared. Results After treatment, FPG, 2hPG, HbAlc levels of two groups were significantly lower than before treatment, the difference was statistically significant（P〈0.05）; the FPG, 2hPG, HbAlc levels, blood glucose time, hypoglycemia the rate and amount of insulin showed no significant difference between the observation group and the control group after treatment（P〉0.05）. Conclusion The clinical effect in patients with type 2 diabetes with insulin aspart insulin detemir therapy is similar with insulin aspart alone, can effectively de- crease blood sugar levels in patients, have higher security.

关 键 词：2型糖尿病 门冬胰岛素 地特胰岛素 

分 类 号：R587.1[医药卫生—内分泌]