响应面法优化二氢杨梅素半合成杨梅素  

Optimization of Semisynthetic Myricetin from Dihydromyricetion by Response Surface Process

作　　者：刘同方[1] 于华忠[1] 陈雁梅 王亭[1] 

机构地区：[1]吉首大学林产化工工程湖南省重点实验室,湖南张家界427000

出　　处：《林产化学与工业》2015年第4期125-130,共6页Chemistry and Industry of Forest Products

基　　金：湖南省高校科技创新团队支持计划(湘教通(2010)212号)

摘　　要：以显齿蛇葡萄叶中含量丰富且易于提取的二氢杨梅素(DMY)为原料,半合成得到杨梅素(MYR)。产物经FI-IR,1H NMR和13C NMR结构鉴定,确认是杨梅素。在单因素试验的基础上,选取吡啶体积分数、料液比和反应温度为影响因子,以MYR得率作为响应值,进行响应面分析(RSM)。结果表明,MYR的最佳合成工艺参数为:吡啶体积分数66.6%、反应温度90.4℃、料液比值为20.88时MYR得率为76.63%,与预测值76.48%的相对误差为0.19%。Dihydromyricetion（ DMY）, which was abundant and easily extracted from the leaves of Ampelopsis grossedentata, was used as the semisynthetic sources for myricetin（MYR）. The structure of MYR was characterized by IR, ^1H NMR and ^13C NMR. Based on the results of the single factor experiments, response surface methodology（RSM） was applied to further optimize the synthesis conditions with pyridine volume fraction, and temperature, solid-liquid-ratio as the impact factors and MYR yield as the response value. The most suitable synthesis conditions of MYR were determined as follows： pyridine volume fraction 66.6% , temperature 90.4℃ and solid-liquid ratio 20.88（ g： L）. The MYR yield was 76.63%, and the relative error with the predictive value of 76.48% was 0.19%.

关 键 词：二氢杨梅素 半合成 杨梅素 响应面分析 

分 类 号：TQ35[化学工程]