KBrO_3-HBr-甲醇体系中苯乙酮类化合物的单溴代反应  

Selectiveα-Monobromination of Acetophenones in KBrO_3-HBr-methanol System

作　　者：郑祖彪[1] 韩冰冰[1] 牛青龙 何在明 

机构地区：[1]黄山学院化学化工学院,安徽黄山245041

出　　处：《化学世界》2015年第8期479-482,共4页Chemical World

摘　　要：在KBrO3-HBr-甲醇体系中,对苯乙酮类化合物的羰基α位单溴代反应进行探讨,分别考察了苯乙酮与溴酸钾及氢溴酸的配比、反应溶剂、反应温度及时间等因素对反应的影响。较优反应条件为：苯乙酮6.0mmol,溴酸钾2.4mmol,氢溴酸7.2mmol,溶剂甲醇15mL,回流条件下反应2h。在此条件下,α-溴代苯乙酮类化合物的收率可达到57.0%-95.1%。In KBrO3-HBr-methanol system, the selective a-monobromination of acetophenones was studied. The effects of the ratio of acetophenones, KBrO3 and HBr, reaction solvent, time and temperature were investigated. The optimal conditions were as follows： acetophenones 6.0 mmol, KBrO3 2.4 mmol, HBr 7.2 mmol,methanol 15 mL,reaction time 2 h under reflux. Under these conditions, the yields of α-bromoaceto-phenones obtained were 57.0%-95.1%.

关 键 词：α-溴代苯乙酮 KBrO3-HBr-甲醇体系 单溴代 选择性 

分 类 号：O623.64[理学—有机化学]