氟比洛芬酯治疗大鼠坐骨神经痛  

Therapeutic effect of flurbiprofen axetil on ischialgia in rats with chronic constriction injury

作　　者：毛豪丽[1] 刘春芳[1] 姜虹[1] 黄燕[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院麻醉科,上海200011

出　　处：《上海医学》2015年第6期466-468,共3页Shanghai Medical Journal

摘　　要：目的观察氟比洛芬酯治疗慢性缩窄性损伤(CCI)模型模拟大鼠坐骨神经慢性疼痛的效果。方法36只雄性Sprague-Dawley(SD)大鼠随机分入6组,每组6只:氟比洛芬酯治疗CCI组,脂肪乳剂治疗CCI组,安慰剂治疗CCI组,CCI组,氟比洛芬酯治疗假手术组,假手术组。制作动物模型前将大鼠称重记录,测试基础疼痛阈值。4个CCI组用线疏松结扎大鼠右侧坐骨神经制备坐骨神经痛模型,疼痛阈值检测确定坐骨神经CCI在术后15d达到高峰期。2个假手术组大鼠仅暴露但不结扎右侧坐骨神经。在疼痛阈值达峰值的术后15d,大鼠称重后,氟比洛芬酯治疗CCI组大鼠尾静脉注射氟比洛芬酯5mg/kg,脂肪乳剂治疗CCI组大鼠尾静脉注射脂肪乳剂5mg/kg,安慰剂治疗CCI组大鼠尾静脉注射相同容量的0.9%氯化钠溶液,氟比洛芬酯治疗假手术组大鼠尾静脉注射氟比洛芬酯5mg/kg。用药组注射药物前和注射药物后15min测定大鼠的疼痛阈值。结果 CCI模型大鼠与行假手术的大鼠间术前体重的差异无统计学意义(P>0.05),术后15d的体重均有增加,CCI模型大鼠与术前的差异无统计学意义(P>0.05),行假手术的大鼠较术前显著增加(P<0.05)。6组间大鼠术前的疼痛阈值的差异均无统计学意义(P值均>0.05)。4个CCI组大鼠术后15d注射药物前的疼痛阈值均较同组术前显著降低(P值均<0.05),出现痛觉敏感;2个假手术组大鼠手术前后疼痛阈值的差异均无统计学意义(P值均>0.05)。注射药物后15min,氟比洛芬酯治疗CCI组大鼠的疼痛阈值显著高于同组注射药物前(P<0.05),而脂肪乳剂治疗CCI组、安慰剂治疗CCI组和氟比洛芬酯治疗假手术组注射药物前后疼痛阈值的差异均无统计学意义(P值均>0.05)。结论氟比洛芬酯治疗CCI模型模拟大鼠坐骨神经慢性疼痛的效果良好。Objective To observe therapeutic effect of flurbiprofen axetil （FA） on chronic constriction injury （CCI） induced chronic pain of ischiadic nerve in rats. Methods Thirty-six male Sprague-Dawley rats were randomly divided into 6 groups （n = 6） .. FA-treated CCI group, intralipid-treated CCI group, placebo-treated COl group, CCI group, FA-treated sham operation group, and sham operation group. All the rats were weighed and their pain threshold was measured before operation. The right ischiadic nerve of rat was exposed and ligated to construct CCI model, while it was only explored during sham operation. Pain threshold reached the peak 15 d after operation and the rats were weighed again. Then FA （5 mg/kg）, intralipid （5 mg/kg） and placebo （the same volume of 0.9% sodium chloride solution） were given through tail vein in the corresponding groups. Pain threshold was measured 15 min before and after injection. Results No significant difference was found in preoperative body weight or pain threshold between groups （all P〉0.05）. Compared with preoperative one, body weight slightly increased on day 15 after operation in 4 CCI groups （P〉0.05）, while significantly increased in 2 sham operation groups （P〈0.05）. In the 4 CCI groups, pain thresholds at 15 d after operation were significantly lower than preoperative one （all P〈0. 05） and hyperalgesia occurred. No significant differences were found between preoperative and postoperative pain threshold in 2 sham operation groups （both P〉0.05）. In the FA-treated CCI group, pain threshold at 15 min after FA injection was significantly higher than that before injection （P〈0.05）.However, no significant differences were found in pain threshold before and after treatment in intralipid-treated CCI group, placebo-treated COl group, or FA-treated sham operation group （all P〉0.05）. Conclusion Flurbiprofen Axetil can significantly reduce chronic pain in the rat models of ischiadic nerve CCI.

关 键 词：氟比洛芬酯 慢性缩窄性损伤 痛阈 

分 类 号：R614[医药卫生—麻醉学]