耳前耳后注射地塞米松及庆大霉素治疗梅尼埃病的疗效观察  

Observation on effect of prootic and opisthotic injection of dexamethasone and gentamicin for treating meniere disease

作　　者：王智勇[1] 苏丽娟[2] 唐强[1] 禹林[1] 蒋中莉 熊玉林[1] 姜浩平 莫明明[1] 

机构地区：[1]重庆市合川区人民医院耳鼻咽喉头颈外科,401520 [2]重庆市合川区人民医院门诊部,401520

出　　处：《检验医学与临床》2015年第16期2320-2322,共3页Laboratory Medicine and Clinic

基　　金：重庆市卫生和计划生育委员会医学科研项目(2013-2-231)

摘　　要：目的观察耳前耳后注射地塞米松、庆大霉素治疗梅尼埃病(MD)的临床疗效。方法选取2011年6月至2014年1月该院就诊的MD患者96例,根据随机原则将患者分为3组:地塞米松组(DX组)、庆大霉素组(GM组),生理盐水组(NS组)。按试验设计采用地塞米松、庆大霉素分别耳前、耳后各注射0.5mL,每周1次,共给药4次,按时观察听功能,前庭功能变化情况以及活动能力的控制情况。结果治疗18个月后,DX组眩晕控制率72.73%,GM组眩晕控制率75.86%,NS组眩晕控制率12.12%,DX组与NS组、GM组与NS组眩晕控制率比较,差异有统计学意义(P<0.01),DX组、GM组对眩晕控制均有效;DX组听力改善率39.39%,GM组听力改善率6.89%,NS组听力改善率9.09%,DX组与GM、NS组比较,听力改善差异有统计学意义(P<0.01),DX组对听力改善有效;DX组活动能力改善率75.76%,GM组活动能力改善率72.41%,NS组活动能力改善率15.15%,DX组与NS组、GM组与NS组活动能力控制率比较差异有统计学意义(P<0.01),DX组、GM组对活动能力控制均有效。结论经耳前耳后分别注射地塞米松、庆大霉素是一条治疗MD简单安全有效的新途径。Objective To observe the clinical curative effect of prootic and opisthotic injection of dexametha- sone and gentamicin for treating Meniere disease（MD）. Methods 96 patients with MD in our hospital from June 2011 to January 2014 were selected and randomly divided into the dexamethasone group（DX group）, gentamycin group（GM group） and the normal saline group（NS group）. According to the experimental design, gentamycin 0.5 mL and dexamethasone 0.5 mL were given by prootic and opisthotic injection,once per week, totally 4 times. The hearing function,vestibular function and control situation of mobility capacity were regularly observed. Results After 18-month treatment,the vertigo control rate was 72.73% in the DX group,75.86% in the GM group and 12.12% in the NS group,the differences between the DX group and the NS group and between the GM group and the NS group had statistical significance （P〈0. 01） ,the vertigo control in the DX group and the GM group were proved to be ef- fective;the improvement rate of hearing function was 39.39% in the DX group,6.89% in the GM group and 9.09% in the NS group,the difference between the DX group and the GM group had statistical significance （P〈0.01） ;the improvement rate of mobility capacity was 75.76% in the DX group,72.41% in the GM group and 15. 15% in the NS group, the differences between the DX group and the NS group and between the GM group and the NS group had statistical significance （P〈0. 01）, the mobility capacity was effectively controlled in the DX group and the GM group. Conclusion Prootic and opisthotic injection of dexamethasone and gentamicin for treating MD is a simple,safe and effective new path for treating MD.

关 键 词：梅尼埃病 地塞米松 庆大霉素 耳前注射 耳后注射 

分 类 号：R978.12[医药卫生—药品]