慢性HCV感染者白细胞介素(IL)家族部分细胞因子含量的变化研究  

Study of the changes of cytokine levels in interleukins family in patients with chronic HCV infection

作　　者：陈琦[1] 杨茹 

机构地区：[1]武汉血液中心,湖北武汉430030

出　　处：《中国输血杂志》2015年第7期791-793,共3页Chinese Journal of Blood Transfusion

基　　金：武汉市卫生局科研项目(WX08B16)

摘　　要：目的探讨慢性HCV感染者感染慢性化产生与白细胞介素(IL)家族细胞因子含量变化的关系。方法收集慢性HCV感染者及健康人群的血液标本各40人份,ELISA法检测血液中IL-2、IL-4、IL-5、IL-6、IL-12、IL-18细胞因子含量变化。结果 HCV感染者和健康人群的IL-2、IL-5、IL-18(pg/m L)分别为:0.28±0.44 vs 1.37±1.36、75.83±37.22 vs 43.78±34.45、633.17±174.75 vs 122.47±32.25(P<0.05)。结论 Th1和Th2型细胞因子都参与了HCV慢性化的进程,IL-2、IL-5、及IL-18在导致HCV感染慢性化进程中可能起了一定的作用。Objective To investigate the reason behind chronic HCV infection in patients by observing the change in the levels of cytokines in interleukins family. Methods 40 samples of blood from chronic HCV infected and healthy people were collected for ELISA on the content of IL-2,IL-4,IL-5,IL-6,IL-12 and IL-18. The variation in the level of cytokines was observed. Results The levels of IL-2,IL-5 and IL-18 were 0. 28 ± 0. 44 vs 1. 37 ± 1. 36,75. 83 ± 37. 22 vs 43. 78 ±34. 45,633. 17 ± 174. 75 vs 122. 47 ± 32. 25,respectively（ P〈 0. 05）. Conclusion Th1 and Th2 cytokines are involved in the process of development of HCV chronic infection. IL-2,IL-5and IL-18 may play a role as well in the process of the development of HCV chronic infection.

关 键 词：慢性HCV感染者 白细胞介素家族 细胞因子 感染慢性化 

分 类 号：R446.6[医药卫生—诊断学] R512.63[医药卫生—临床医学]