4-乙酰氧基-2-甲基-2-丁烯-1-醛的合成  

Synthesis of 4-acetoxy-2-methyl-2-butenal

作　　者：廖艳金 方泽华 廖元统 

机构地区：[1]广州巨元生化有限公司,广东广州510000 [2]肇庆巨元生化有限公司,广东肇庆526238

出　　处：《广州化工》2015年第16期116-117,167,共3页GuangZhou Chemical Industry

摘　　要：以异戊二烯为原料,与三氯异氰尿酸发生氯醇化反应,生成1,2加成和1,4加成产物混合物,加成产物混合物在浓硫酸为催化剂的条件下与乙酸酐发生酯化反应,酯化结束后直接升温进行转位反应生成1-乙酰氧基-4-氯-3-甲基-2-丁烯。之后在复合催化剂磷酸氢二钾、磷酸二氢钾和二甲基亚砜的条件下,用TEMPO氧化为目标产物4-乙酰氧基-2-甲基-2-丁烯-1-醛。Using isoprene methyl butane as starting material in the chlorohydrination with trichloroiminocyanuric acid, I, 2 and I, 4-addition production mixture was formed. Following in the presence of concentrated sulfuric acid and esterification with acetic anhydride, heating directly for rearrangement, 1-acetoxy-4-chloro-3-methyl-2-butene was obtained. Using dipotassium phosphate, potassium dihydrogen phosphate and DMSO as complexing catalyst, desired product 4-acetoxy-2-methyl-2-butenal was synthesized by oxidation with TEMPO.

关 键 词：异戊二烯 中间体 4-乙酰氧基-2-甲基-2-丁烯-1-醛 合成 

分 类 号：TQ221.213[化学工程—有机化工]